Peterkin V - Search Results

1

Drug-drug interactions for UDP-glucuronosyltransferase substrates: a pharmacokinetic explanation for typically observed low exposure (AUCi/AUC) ratios.

Williams JA, Hyland R, Jones BC, Smith DA, Hurst S, Goosen TC, Peterkin V, Koup JR, Ball SE. Williams JA, et al. Among authors: peterkin v. Drug Metab Dispos. 2004 Nov;32(11):1201-8. doi: 10.1124/dmd.104.000794. Epub 2004 Aug 10. Drug Metab Dispos. 2004. PMID: 15304429 Review.

2

Udp-glucuronosyltransferase 2b7 is the major enzyme responsible for gemcabene glucuronidation in human liver microsomes.

Bauman JN, Goosen TC, Tugnait M, Peterkin V, Hurst SI, Menning LC, Milad M, Court MH, Williams JA. Bauman JN, et al. Among authors: peterkin v. Drug Metab Dispos. 2005 Sep;33(9):1349-54. doi: 10.1124/dmd.105.005108. Epub 2005 Jun 24. Drug Metab Dispos. 2005. PMID: 15980101

3

Limited influence of UGT1A1*28 and no effect of UGT2B7*2 polymorphisms on UGT1A1 or UGT2B7 activities and protein expression in human liver microsomes.

Peterkin VC, Bauman JN, Goosen TC, Menning L, Man MZ, Paulauskis JD, Williams JA, Myrand SP. Peterkin VC, et al. Br J Clin Pharmacol. 2007 Oct;64(4):458-68. doi: 10.1111/j.1365-2125.2007.02923.x. Epub 2007 Jun 6. Br J Clin Pharmacol. 2007. PMID: 17555467 Free PMC article.

4

A humanized UGT1 mouse model expressing the UGT1A1*28 allele for assessing drug clearance by UGT1A1-dependent glucuronidation.

Cai H, Nguyen N, Peterkin V, Yang YS, Hotz K, La Placa DB, Chen S, Tukey RH, Stevens JC. Cai H, et al. Among authors: peterkin v. Drug Metab Dispos. 2010 May;38(5):879-86. doi: 10.1124/dmd.109.030130. Epub 2010 Feb 2. Drug Metab Dispos. 2010. PMID: 20124398 Free PMC article.

5

Modulation of cellular S1P levels with a novel, potent and specific inhibitor of sphingosine kinase-1.

Schnute ME, McReynolds MD, Kasten T, Yates M, Jerome G, Rains JW, Hall T, Chrencik J, Kraus M, Cronin CN, Saabye M, Highkin MK, Broadus R, Ogawa S, Cukyne K, Zawadzke LE, Peterkin V, Iyanar K, Scholten JA, Wendling J, Fujiwara H, Nemirovskiy O, Wittwer AJ, Nagiec MM. Schnute ME, et al. Among authors: peterkin v. Biochem J. 2012 May 15;444(1):79-88. doi: 10.1042/BJ20111929. Biochem J. 2012. PMID: 22397330

6

Validation of a total IC₅₀ method which enables in vitro assessment of transporter inhibition under semi-physiological conditions.

Kikuchi R, Peterkin VC, Chiou WJ, de Morais SM, Bow DAJ. Kikuchi R, et al. Among authors: peterkin vc. Xenobiotica. 2017 Sep;47(9):825-832. doi: 10.1080/00498254.2016.1233372. Epub 2016 Oct 3. Xenobiotica. 2017. PMID: 27609543

7

Challenges and Opportunities for In Vitro-In Vivo Extrapolation of Aldehyde Oxidase-Mediated Clearance: Toward a Roadmap for Quantitative Translation.

Izat N, Bolleddula J, Abbasi A, Cheruzel L, Jones RS, Moss D, Ortega-Muro F, Parmentier Y, Peterkin VC, Tian DD, Venkatakrishnan K, Zientek MA, Barber J, Houston JB, Galetin A, Scotcher D. Izat N, et al. Among authors: peterkin vc. Drug Metab Dispos. 2023 Dec;51(12):1591-1606. doi: 10.1124/dmd.123.001436. Epub 2023 Sep 26. Drug Metab Dispos. 2023. PMID: 37751998

8

A High Throughput, 384-Well, Semi-Automated, Hepatocyte Intrinsic Clearance Assay for Screening New Molecular Entities in Drug Discovery.

Heinle L, Peterkin V, de Morais SM, Jenkins GJ, Badagnani I. Heinle L, et al. Among authors: peterkin v. Comb Chem High Throughput Screen. 2015;18(5):442-52. doi: 10.2174/1386207318666150401101737. Comb Chem High Throughput Screen. 2015. PMID: 25828461

9

Synthesis and evaluation of 2'-dihalo ribonucleotide prodrugs with activity against hepatitis C virus.

Chris Krueger A, Chen HJ, Randolph JT, Brown BS, Halvorsen GT, Heyman HR, Li T, Marvin CC, Shanley JP, Voight EA, Bow DAJ, Van Handel C, Peterkin V, Carr RA, Stolarik D, Dekhtyar T, Irvin ML, Krishnan P, Henry RF, Wagner R, DeGoey DA. Chris Krueger A, et al. Among authors: peterkin v. Bioorg Med Chem. 2020 Jan 1;28(1):115208. doi: 10.1016/j.bmc.2019.115208. Epub 2019 Nov 11. Bioorg Med Chem. 2020. PMID: 31740203

10

Discovery of 2-aminoisobutyric acid ethyl ester (AIBEE) phosphoramidate prodrugs for delivering nucleoside HCV NS5B polymerase inhibitors.

Randolph JT, Li T, Chris Krueger A, Heyman HR, Chen HJ, Bow DAJ, Van Handel C, Peterkin V, Carr RA, Stolarik D, Dekhtyar T, Irvin M, Krishnan P, Wagner R, DeGoey DA. Randolph JT, et al. Among authors: peterkin v. Bioorg Med Chem Lett. 2020 Apr 1;30(7):126986. doi: 10.1016/j.bmcl.2020.126986. Epub 2020 Jan 25. Bioorg Med Chem Lett. 2020. PMID: 32046903

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