Serabjit-Singh CJ - Search Results

1

In vitro absorption and secretory quotients: practical criteria derived from a study of 331 compounds to assess for the impact of P-glycoprotein-mediated efflux on drug candidates.

Thiel-Demby VE, Tippin TK, Humphreys JE, Serabjit-Singh CJ, Polli JW. Thiel-Demby VE, et al. Among authors: serabjit singh cj. J Pharm Sci. 2004 Oct;93(10):2567-72. doi: 10.1002/jps.20166. J Pharm Sci. 2004. PMID: 15349966

2

Passive permeability and P-glycoprotein-mediated efflux differentiate central nervous system (CNS) and non-CNS marketed drugs.

Mahar Doan KM, Humphreys JE, Webster LO, Wring SA, Shampine LJ, Serabjit-Singh CJ, Adkison KK, Polli JW. Mahar Doan KM, et al. Among authors: serabjit singh cj. J Pharmacol Exp Ther. 2002 Dec;303(3):1029-37. doi: 10.1124/jpet.102.039255. J Pharmacol Exp Ther. 2002. PMID: 12438524

3

P-glycoprotein influences the brain concentrations of cetirizine (Zyrtec), a second-generation non-sedating antihistamine.

Polli JW, Baughman TM, Humphreys JE, Jordan KH, Mote AL, Salisbury JA, Tippin TK, Serabjit-Singh CJ. Polli JW, et al. Among authors: serabjit singh cj. J Pharm Sci. 2003 Oct;92(10):2082-9. doi: 10.1002/jps.10453. J Pharm Sci. 2003. PMID: 14502547

4

The systemic exposure of an N-methyl-D-aspartate receptor antagonist is limited in mice by the P-glycoprotein and breast cancer resistance protein efflux transporters.

Polli JW, Baughman TM, Humphreys JE, Jordan KH, Mote AL, Webster LO, Barnaby RJ, Vitulli G, Bertolotti L, Read KD, Serabjit-Singh CJ. Polli JW, et al. Among authors: serabjit singh cj. Drug Metab Dispos. 2004 Jul;32(7):722-6. doi: 10.1124/dmd.32.7.722. Drug Metab Dispos. 2004. PMID: 15205387

5

In vitro p-glycoprotein inhibition assays for assessment of clinical drug interaction potential of new drug candidates: a recommendation for probe substrates.

Rautio J, Humphreys JE, Webster LO, Balakrishnan A, Keogh JP, Kunta JR, Serabjit-Singh CJ, Polli JW. Rautio J, et al. Among authors: serabjit singh cj. Drug Metab Dispos. 2006 May;34(5):786-92. doi: 10.1124/dmd.105.008615. Epub 2006 Feb 2. Drug Metab Dispos. 2006. PMID: 16455806

6

Steady-state brain concentrations of antihistamines in rats: interplay of membrane permeability, P-glycoprotein efflux and plasma protein binding.

Mahar Doan KM, Wring SA, Shampine LJ, Jordan KH, Bishop JP, Kratz J, Yang E, Serabjit-Singh CJ, Adkison KK, Polli JW. Mahar Doan KM, et al. Among authors: serabjit singh cj. Pharmacology. 2004 Oct;72(2):92-8. doi: 10.1159/000079137. Pharmacology. 2004. PMID: 15331914

7

The role of efflux and uptake transporters in [N-{3-chloro-4-[(3-fluorobenzyl)oxy]phenyl}-6-[5-({[2-(methylsulfonyl)ethyl]amino}methyl)-2-furyl]-4-quinazolinamine (GW572016, lapatinib) disposition and drug interactions.

Polli JW, Humphreys JE, Harmon KA, Castellino S, O'Mara MJ, Olson KL, John-Williams LS, Koch KM, Serabjit-Singh CJ. Polli JW, et al. Among authors: serabjit singh cj. Drug Metab Dispos. 2008 Apr;36(4):695-701. doi: 10.1124/dmd.107.018374. Epub 2008 Jan 23. Drug Metab Dispos. 2008. PMID: 18216274

8

Evaluation of a chimeric (uPA+/+)/SCID mouse model with a humanized liver for prediction of human metabolism.

De Serres M, Bowers G, Boyle G, Beaumont C, Castellino S, Sigafoos J, Dave M, Roberts A, Shah V, Olson K, Patel D, Wagner D, Yeager R, Serabjit-Singh C. De Serres M, et al. Xenobiotica. 2011 Jun;41(6):464-75. doi: 10.3109/00498254.2011.560295. Epub 2011 Mar 4. Xenobiotica. 2011. PMID: 21370990

9

Automated quantitative and qualitative analysis of metabolic stability: a process for compound selection during drug discovery.

Wring SA, Silver IS, Serabjit-Singh CJ. Wring SA, et al. Among authors: serabjit singh cj. Methods Enzymol. 2002;357:285-95. doi: 10.1016/s0076-6879(02)57686-2. Methods Enzymol. 2002. PMID: 12424918 No abstract available.

10

Multiple forms of cytochrome P450 are involved in the metabolism of ondansetron in humans.

Dixon CM, Colthup PV, Serabjit-Singh CJ, Kerr BM, Boehlert CC, Park GR, Tarbit MH. Dixon CM, et al. Drug Metab Dispos. 1995 Nov;23(11):1225-30. Drug Metab Dispos. 1995. PMID: 8591723

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