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Mechano-transduction in osteoblastic cells involves strain-regulated estrogen receptor alpha-mediated control of insulin-like growth factor (IGF) I receptor sensitivity to Ambient IGF, leading to phosphatidylinositol 3-kinase/AKT-dependent Wnt/LRP5 receptor-independent activation of beta-catenin signaling.
Sunters A, Armstrong VJ, Zaman G, Kypta RM, Kawano Y, Lanyon LE, Price JS. Sunters A, et al. Among authors: kypta rm. J Biol Chem. 2010 Mar 19;285(12):8743-58. doi: 10.1074/jbc.M109.027086. Epub 2009 Dec 30. J Biol Chem. 2010. PMID: 20042609 Free PMC article.
Distinct expression and activity of GSK-3α and GSK-3β in prostate cancer.
Darrington RS, Campa VM, Walker MM, Bengoa-Vergniory N, Gorrono-Etxebarria I, Uysal-Onganer P, Kawano Y, Waxman J, Kypta RM. Darrington RS, et al. Among authors: kypta rm. Int J Cancer. 2012 Sep 15;131(6):E872-83. doi: 10.1002/ijc.27620. Epub 2012 May 22. Int J Cancer. 2012. PMID: 22539113
57 results