Hartley JA - Search Results

1

SJG-136 (NSC 694501), a novel rationally designed DNA minor groove interstrand cross-linking agent with potent and broad spectrum antitumor activity: part 2: efficacy evaluations.

Alley MC, Hollingshead MG, Pacula-Cox CM, Waud WR, Hartley JA, Howard PW, Gregson SJ, Thurston DE, Sausville EA. Alley MC, et al. Among authors: hartley ja. Cancer Res. 2004 Sep 15;64(18):6700-6. doi: 10.1158/0008-5472.CAN-03-2942. Cancer Res. 2004. PMID: 15374987

2

DNA cross-linking and sequence selectivity of aziridinylbenzoquinones: a unique reaction at 5'-GC-3' sequences with 2,5-diaziridinyl-1,4-benzoquinone upon reduction.

Hartley JA, Berardini M, Ponti M, Gibson NW, Thompson AS, Thurston DE, Hoey BM, Butler J. Hartley JA, et al. Biochemistry. 1991 Dec 17;30(50):11719-24. doi: 10.1021/bi00114a016. Biochemistry. 1991. PMID: 1751490

3

N2,N4,N6-tri(hydroxymethyl)-N2,N4,N6-trimethylmelamine (trimelamol) is an efficient DNA cross-linking agent in vitro.

Jackson C, Hartley JA, Jenkins TC, Godfrey R, Saunders R, Thurston DE. Jackson C, et al. Among authors: hartley ja. Biochem Pharmacol. 1991 Nov 6;42(11):2091-7. doi: 10.1016/0006-2952(91)90343-4. Biochem Pharmacol. 1991. PMID: 1958227

4

Cellular pharmacology of novel C8-linked anthramycin-based sequence-selective DNA minor groove cross-linking agents.

Smellie M, Kelland LR, Thurston DE, Souhami RL, Hartley JA. Smellie M, et al. Among authors: hartley ja. Br J Cancer. 1994 Jul;70(1):48-53. doi: 10.1038/bjc.1994.248. Br J Cancer. 1994. PMID: 8018540 Free PMC article.

5

A quantitative assay to measure the relative DNA-binding affinity of pyrrolo[2,1-c] [1,4]benzodiazepine (PBD) antitumour antibiotics based on the inhibition of restriction endonuclease BamHI.

Puvvada MS, Hartley JA, Jenkins TC, Thurston DE. Puvvada MS, et al. Among authors: hartley ja. Nucleic Acids Res. 1993 Aug 11;21(16):3671-5. doi: 10.1093/nar/21.16.3671. Nucleic Acids Res. 1993. PMID: 8367284 Free PMC article.

6

Design, synthesis, and evaluation of a novel sequence-selective epoxide-containing DNA cross-linking agent based on the pyrrolo[2, 1-c][1,4]benzodiazepine system.

Wilson SC, Howard PW, Forrow SM, Hartley JA, Adams LJ, Jenkins TC, Kelland LR, Thurston DE. Wilson SC, et al. Among authors: hartley ja. J Med Chem. 1999 Oct 7;42(20):4028-41. doi: 10.1021/jm981124d. J Med Chem. 1999. PMID: 10514273

7

Design, synthesis, and evaluation of a novel pyrrolobenzodiazepine DNA-interactive agent with highly efficient cross-linking ability and potent cytotoxicity.

Gregson SJ, Howard PW, Hartley JA, Brooks NA, Adams LJ, Jenkins TC, Kelland LR, Thurston DE. Gregson SJ, et al. Among authors: hartley ja. J Med Chem. 2001 Mar 1;44(5):737-48. doi: 10.1021/jm001064n. J Med Chem. 2001. PMID: 11262084

8

Synthesis of Sequence-Selective C8-Linked Pyrrolo[2,1-c][1,4]benzodiazepine DNA Interstrand Cross-Linking Agents.

Thurston DE, Bose DS, Thompson AS, Howard PW, Leoni A, Croker SJ, Jenkins TC, Neidle S, Hartley JA, Hurley LH. Thurston DE, et al. Among authors: hartley ja. J Org Chem. 1996 Nov 15;61(23):8141-8147. doi: 10.1021/jo951631s. J Org Chem. 1996. PMID: 11667802

9

Sequence-selective recognition of duplex DNA through covalent interstrand cross-linking: kinetic and molecular modeling studies with pyrrolobenzodiazepine dimers.

Smellie M, Bose DS, Thompson AS, Jenkins TC, Hartley JA, Thurston DE. Smellie M, et al. Among authors: hartley ja. Biochemistry. 2003 Jul 15;42(27):8232-9. doi: 10.1021/bi034313t. Biochemistry. 2003. PMID: 12846572

10

Linker length modulates DNA cross-linking reactivity and cytotoxic potency of C8/C8' ether-linked C2-exo-unsaturated pyrrolo[2,1-c][1,4]benzodiazepine (PBD) dimers.

Gregson SJ, Howard PW, Gullick DR, Hamaguchi A, Corcoran KE, Brooks NA, Hartley JA, Jenkins TC, Patel S, Guille MJ, Thurston DE. Gregson SJ, et al. Among authors: hartley ja. J Med Chem. 2004 Feb 26;47(5):1161-74. doi: 10.1021/jm030897l. J Med Chem. 2004. PMID: 14971896

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