Kopan R - Search Results

1

Ectodomain shedding and intramembrane cleavage of mammalian Notch proteins is not regulated through oligomerization.

Vooijs M, Schroeter EH, Pan Y, Blandford M, Kopan R. Vooijs M, et al. Among authors: kopan r. J Biol Chem. 2004 Dec 3;279(49):50864-73. doi: 10.1074/jbc.M409430200. Epub 2004 Sep 23. J Biol Chem. 2004. PMID: 15448134 Free article.

2

Cell surface presenilin-1 participates in the gamma-secretase-like proteolysis of Notch.

Ray WJ, Yao M, Mumm J, Schroeter EH, Saftig P, Wolfe M, Selkoe DJ, Kopan R, Goate AM. Ray WJ, et al. Among authors: kopan r. J Biol Chem. 1999 Dec 17;274(51):36801-7. doi: 10.1074/jbc.274.51.36801. J Biol Chem. 1999. PMID: 10593990 Free article.

3

Murine notch homologs (N1-4) undergo presenilin-dependent proteolysis.

Saxena MT, Schroeter EH, Mumm JS, Kopan R. Saxena MT, et al. Among authors: kopan r. J Biol Chem. 2001 Oct 26;276(43):40268-73. doi: 10.1074/jbc.M107234200. Epub 2001 Aug 22. J Biol Chem. 2001. PMID: 11518718 Free article.

4

Notch-1 signalling requires ligand-induced proteolytic release of intracellular domain.

Schroeter EH, Kisslinger JA, Kopan R. Schroeter EH, et al. Among authors: kopan r. Nature. 1998 May 28;393(6683):382-6. doi: 10.1038/30756. Nature. 1998. PMID: 9620803

5

gamma-secretase functions through Notch signaling to maintain skin appendages but is not required for their patterning or initial morphogenesis.

Pan Y, Lin MH, Tian X, Cheng HT, Gridley T, Shen J, Kopan R. Pan Y, et al. Among authors: kopan r. Dev Cell. 2004 Nov;7(5):731-43. doi: 10.1016/j.devcel.2004.09.014. Dev Cell. 2004. PMID: 15525534 Free article.

6

Mapping the consequence of Notch1 proteolysis in vivo with NIP-CRE.

Vooijs M, Ong CT, Hadland B, Huppert S, Liu Z, Korving J, van den Born M, Stappenbeck T, Wu Y, Clevers H, Kopan R. Vooijs M, et al. Among authors: kopan r. Development. 2007 Feb;134(3):535-44. doi: 10.1242/dev.02733. Development. 2007. PMID: 17215306 Free PMC article.

7

Metalloprotease ADAM10 is required for Notch1 site 2 cleavage.

van Tetering G, van Diest P, Verlaan I, van der Wall E, Kopan R, Vooijs M. van Tetering G, et al. Among authors: kopan r. J Biol Chem. 2009 Nov 6;284(45):31018-27. doi: 10.1074/jbc.M109.006775. Epub 2009 Sep 2. J Biol Chem. 2009. PMID: 19726682 Free PMC article.

8

A presenilin dimer at the core of the gamma-secretase enzyme: insights from parallel analysis of Notch 1 and APP proteolysis.

Schroeter EH, Ilagan MX, Brunkan AL, Hecimovic S, Li YM, Xu M, Lewis HD, Saxena MT, De Strooper B, Coonrod A, Tomita T, Iwatsubo T, Moore CL, Goate A, Wolfe MS, Shearman M, Kopan R. Schroeter EH, et al. Among authors: kopan r. Proc Natl Acad Sci U S A. 2003 Oct 28;100(22):13075-80. doi: 10.1073/pnas.1735338100. Epub 2003 Oct 17. Proc Natl Acad Sci U S A. 2003. PMID: 14566063 Free PMC article.

9

Embryonic lethality in mice homozygous for a processing-deficient allele of Notch1.

Huppert SS, Le A, Schroeter EH, Mumm JS, Saxena MT, Milner LA, Kopan R. Huppert SS, et al. Among authors: kopan r. Nature. 2000 Jun 22;405(6789):966-70. doi: 10.1038/35016111. Nature. 2000. PMID: 10879540

10

A ligand-induced extracellular cleavage regulates gamma-secretase-like proteolytic activation of Notch1.

Mumm JS, Schroeter EH, Saxena MT, Griesemer A, Tian X, Pan DJ, Ray WJ, Kopan R. Mumm JS, et al. Among authors: kopan r. Mol Cell. 2000 Feb;5(2):197-206. doi: 10.1016/s1097-2765(00)80416-5. Mol Cell. 2000. PMID: 10882062 Free article.

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