Nichols DA - Search Results

1

A three-dimensional in silico pharmacophore model for inhibition of Plasmodium falciparum cyclin-dependent kinases and discovery of different classes of novel Pfmrk specific inhibitors.

Bhattacharjee AK, Geyer JA, Woodard CL, Kathcart AK, Nichols DA, Prigge ST, Li Z, Mott BT, Waters NC. Bhattacharjee AK, et al. Among authors: nichols da. J Med Chem. 2004 Oct 21;47(22):5418-26. doi: 10.1021/jm040108f. J Med Chem. 2004. PMID: 15481979

2

An in silico 3D pharmacophore model of chalcones useful in the design of novel antimalarial agents.

Bhattacharjee AK, Nichols DA, Gerena L, Roncal N, Gutteridge CE. Bhattacharjee AK, et al. Among authors: nichols da. Med Chem. 2007 Jul;3(4):317-26. doi: 10.2174/157340607781024357. Med Chem. 2007. PMID: 17627568

3

Oxindole-based compounds are selective inhibitors of Plasmodium falciparum cyclin dependent protein kinases.

Woodard CL, Li Z, Kathcart AK, Terrell J, Gerena L, Lopez-Sanchez M, Kyle DE, Bhattacharjee AK, Nichols DA, Ellis W, Prigge ST, Geyer JA, Waters NC. Woodard CL, et al. Among authors: nichols da. J Med Chem. 2003 Aug 28;46(18):3877-82. doi: 10.1021/jm0300983. J Med Chem. 2003. PMID: 12930149

4

Structure-activity relationship study of antimalarial indolo [2,1-b]quinazoline-6,12-diones (tryptanthrins). Three dimensional pharmacophore modeling and identification of new antimalarial candidates.

Bhattacharjee AK, Hartell MG, Nichols DA, Hicks RP, Stanton B, van Hamont JE, Milhous WK. Bhattacharjee AK, et al. Among authors: nichols da. Eur J Med Chem. 2004 Jan;39(1):59-67. doi: 10.1016/j.ejmech.2003.10.004. Eur J Med Chem. 2004. PMID: 14987834

5

Selective inhibition of Pfmrk, a Plasmodium falciparum CDK, by antimalarial 1,3-diaryl-2-propenones.

Geyer JA, Keenan SM, Woodard CL, Thompson PA, Gerena L, Nichols DA, Gutteridge CE, Waters NC. Geyer JA, et al. Among authors: nichols da. Bioorg Med Chem Lett. 2009 Apr 1;19(7):1982-5. doi: 10.1016/j.bmcl.2009.02.042. Epub 2009 Feb 13. Bioorg Med Chem Lett. 2009. PMID: 19250824

6

In vitro efficacy of 2,N-bisarylated 2-ethoxyacetamides against Plasmodium falciparum.

Gutteridge CE, Major JW, Nin DA, Curtis SM, Bhattacharjee AK, Gerena L, Nichols DA. Gutteridge CE, et al. Among authors: nichols da. Bioorg Med Chem Lett. 2016 Feb 1;26(3):1048-1051. doi: 10.1016/j.bmcl.2015.12.032. Epub 2015 Dec 11. Bioorg Med Chem Lett. 2016. PMID: 26750257

7

The medicinal chemistry of botulinum, ricin and anthrax toxins.

Hicks RP, Hartell MG, Nichols DA, Bhattacharjee AK, van Hamont JE, Skillman DR. Hicks RP, et al. Among authors: nichols da. Curr Med Chem. 2005;12(6):667-90. doi: 10.2174/0929867053202223. Curr Med Chem. 2005. PMID: 15790305 Review.

8

In vitro and in vivo efficacy and in vitro metabolism of 1-phenyl-3-aryl-2-propen-1-ones against Plasmodium falciparum.

Gutteridge CE, Nichols DA, Curtis SM, Thota DS, Vo JV, Gerena L, Montip G, Asher CO, Diaz DS, Ditusa CA, Smith KS, Bhattacharjee AK. Gutteridge CE, et al. Among authors: nichols da. Bioorg Med Chem Lett. 2006 Nov 1;16(21):5682-6. doi: 10.1016/j.bmcl.2006.08.009. Epub 2006 Aug 14. Bioorg Med Chem Lett. 2006. PMID: 16908136

9

Comparison of the conformation and electrostatic surface properties of magainin peptides bound to sodium dodecyl sulfate and dodecylphosphocholine micelles.

Hicks RP, Mones E, Kim H, Koser BW, Nichols DA, Bhattacharjee AK. Hicks RP, et al. Among authors: nichols da. Biopolymers. 2003 Apr;68(4):459-70. doi: 10.1002/bip.10325. Biopolymers. 2003. PMID: 12666172

10

Antileishmanial and antimalarial chalcones: synthesis, efficacy and cytotoxicity of pyridinyl and naphthalenyl analogs.

Gutteridge CE, Vo JV, Tillett CB, Vigilante JA, Dettmer JR, Patterson SL, Werbovetz KA, Capers J, Nichols DA, Bhattacharjee AK, Gerena L. Gutteridge CE, et al. Among authors: nichols da. Med Chem. 2007 Mar;3(2):115-9. doi: 10.2174/157340607780059530. Med Chem. 2007. PMID: 17348849

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