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Page 1
Direct agonist/antagonist functions of dehydroepiandrosterone.
Chen F, Knecht K, Birzin E, Fisher J, Wilkinson H, Mojena M, Moreno CT, Schmidt A, Harada S, Freedman LP, Reszka AA. Chen F, et al. Among authors: freedman lp. Endocrinology. 2005 Nov;146(11):4568-76. doi: 10.1210/en.2005-0368. Epub 2005 Jun 30. Endocrinology. 2005. PMID: 15994348
Androgen-mediated improvement of body composition and muscle function involves a novel early transcriptional program including IGF1, mechano growth factor, and induction of {beta}-catenin.
Gentile MA, Nantermet PV, Vogel RL, Phillips R, Holder D, Hodor P, Cheng C, Dai H, Freedman LP, Ray WJ. Gentile MA, et al. Among authors: freedman lp. J Mol Endocrinol. 2010 Jan;44(1):55-73. doi: 10.1677/JME-09-0048. Epub 2009 Sep 2. J Mol Endocrinol. 2010. PMID: 19726620
The LATS2/KPM tumor suppressor is a negative regulator of the androgen receptor.
Powzaniuk M, McElwee-Witmer S, Vogel RL, Hayami T, Rutledge SJ, Chen F, Harada S, Schmidt A, Rodan GA, Freedman LP, Bai C. Powzaniuk M, et al. Among authors: freedman lp. Mol Endocrinol. 2004 Aug;18(8):2011-23. doi: 10.1210/me.2004-0065. Epub 2004 May 6. Mol Endocrinol. 2004. PMID: 15131260
A regulatory circuit mediating convergence between Nurr1 transcriptional regulation and Wnt signaling.
Kitagawa H, Ray WJ, Glantschnig H, Nantermet PV, Yu Y, Leu CT, Harada S, Kato S, Freedman LP. Kitagawa H, et al. Among authors: freedman lp. Mol Cell Biol. 2007 Nov;27(21):7486-96. doi: 10.1128/MCB.00409-07. Epub 2007 Aug 20. Mol Cell Biol. 2007. Retraction in: Mol Cell Biol. 2014 Mar;34(5):917. doi: 10.1128/MCB.00022-14 PMID: 17709391 Free PMC article. Retracted.
Discovery of the selective androgen receptor modulator MK-0773 using a rational development strategy based on differential transcriptional requirements for androgenic anabolism versus reproductive physiology.
Schmidt A, Kimmel DB, Bai C, Scafonas A, Rutledge S, Vogel RL, McElwee-Witmer S, Chen F, Nantermet PV, Kasparcova V, Leu CT, Zhang HZ, Duggan ME, Gentile MA, Hodor P, Pennypacker B, Masarachia P, Opas EE, Adamski SA, Cusick TE, Wang J, Mitchell HJ, Kim Y, Prueksaritanont T, Perkins JJ, Meissner RS, Hartman GD, Freedman LP, Harada S, Ray WJ. Schmidt A, et al. Among authors: freedman lp. J Biol Chem. 2010 May 28;285(22):17054-64. doi: 10.1074/jbc.M109.099002. Epub 2010 Mar 31. J Biol Chem. 2010. PMID: 20356837 Free PMC article.
Antagonist-induced, activation function-2-independent estrogen receptor alpha phosphorylation.
Lipfert L, Fisher JE, Wei N, Scafonas A, Su Q, Yudkovitz J, Chen F, Warrier S, Birzin ET, Kim S, Chen HY, Tan Q, Schmidt A, Dininno F, Rohrer SP, Hammond ML, Rodan GA, Freedman LP, Reszka AA. Lipfert L, et al. Among authors: freedman lp. Mol Endocrinol. 2006 Mar;20(3):516-33. doi: 10.1210/me.2005-0190. Epub 2005 Oct 13. Mol Endocrinol. 2006. PMID: 16223974
150 results