Troutman M - Search Results

1

The impact of P-glycoprotein on the disposition of drugs targeted for indications of the central nervous system: evaluation using the MDR1A/1B knockout mouse model.

Doran A, Obach RS, Smith BJ, Hosea NA, Becker S, Callegari E, Chen C, Chen X, Choo E, Cianfrogna J, Cox LM, Gibbs JP, Gibbs MA, Hatch H, Hop CE, Kasman IN, Laperle J, Liu J, Liu X, Logman M, Maclin D, Nedza FM, Nelson F, Olson E, Rahematpura S, Raunig D, Rogers S, Schmidt K, Spracklin DK, Szewc M, Troutman M, Tseng E, Tu M, Van Deusen JW, Venkatakrishnan K, Walens G, Wang EQ, Wong D, Yasgar AS, Zhang C. Doran A, et al. Among authors: troutman m. Drug Metab Dispos. 2005 Jan;33(1):165-74. doi: 10.1124/dmd.104.001230. Epub 2004 Oct 22. Drug Metab Dispos. 2005. PMID: 15502009

2

The effect of breast cancer resistance protein and P-glycoprotein on the brain penetration of flavopiridol, imatinib mesylate (Gleevec), prazosin, and 2-methoxy-3-(4-(2-(5-methyl-2-phenyloxazol-4-yl)ethoxy)phenyl)propanoic acid (PF-407288) in mice.

Zhou L, Schmidt K, Nelson FR, Zelesky V, Troutman MD, Feng B. Zhou L, et al. Drug Metab Dispos. 2009 May;37(5):946-55. doi: 10.1124/dmd.108.024489. Epub 2009 Feb 18. Drug Metab Dispos. 2009. PMID: 19225039

3

In vitro P-glycoprotein assays to predict the in vivo interactions of P-glycoprotein with drugs in the central nervous system.

Feng B, Mills JB, Davidson RE, Mireles RJ, Janiszewski JS, Troutman MD, de Morais SM. Feng B, et al. Among authors: troutman md. Drug Metab Dispos. 2008 Feb;36(2):268-75. doi: 10.1124/dmd.107.017434. Epub 2007 Oct 25. Drug Metab Dispos. 2008. PMID: 17962372

4

Aldehyde oxidase 1 (AOX1) in human liver cytosols: quantitative characterization of AOX1 expression level and activity relationship.

Fu C, Di L, Han X, Soderstrom C, Snyder M, Troutman MD, Obach RS, Zhang H. Fu C, et al. Among authors: troutman md. Drug Metab Dispos. 2013 Oct;41(10):1797-804. doi: 10.1124/dmd.113.053082. Epub 2013 Jul 15. Drug Metab Dispos. 2013. PMID: 23857892

5

In Vitro-In Vivo Extrapolation of Key Transporter Activity at the Blood-Brain Barrier.

Trapa PE, Troutman MD, Lau TY, Wager TT, Maurer TS, Patel NC, West MA, Umland JP, Carlo AA, Feng B, Liras JL. Trapa PE, et al. Drug Metab Dispos. 2019 Apr;47(4):405-411. doi: 10.1124/dmd.118.083279. Epub 2019 Jan 25. Drug Metab Dispos. 2019. PMID: 30683809

6

High throughput ADME screening: practical considerations, impact on the portfolio and enabler of in silico ADME models.

Hop CE, Cole MJ, Davidson RE, Duignan DB, Federico J, Janiszewski JS, Jenkins K, Krueger S, Lebowitz R, Liston TE, Mitchell W, Snyder M, Steyn SJ, Soglia JR, Taylor C, Troutman MD, Umland J, West M, Whalen KM, Zelesky V, Zhao SX. Hop CE, et al. Among authors: troutman md. Curr Drug Metab. 2008 Nov;9(9):847-53. doi: 10.2174/138920008786485092. Curr Drug Metab. 2008. PMID: 18991580 Review.

7

Physicochemical determinants of human renal clearance.

Varma MV, Feng B, Obach RS, Troutman MD, Chupka J, Miller HR, El-Kattan A. Varma MV, et al. J Med Chem. 2009 Aug 13;52(15):4844-52. doi: 10.1021/jm900403j. J Med Chem. 2009. PMID: 19445515

8

Physicochemical space for optimum oral bioavailability: contribution of human intestinal absorption and first-pass elimination.

Varma MV, Obach RS, Rotter C, Miller HR, Chang G, Steyn SJ, El-Kattan A, Troutman MD. Varma MV, et al. J Med Chem. 2010 Feb 11;53(3):1098-108. doi: 10.1021/jm901371v. J Med Chem. 2010. PMID: 20070106

9

Mechanistic insights from comparing intrinsic clearance values between human liver microsomes and hepatocytes to guide drug design.

Di L, Keefer C, Scott DO, Strelevitz TJ, Chang G, Bi YA, Lai Y, Duckworth J, Fenner K, Troutman MD, Obach RS. Di L, et al. Eur J Med Chem. 2012 Nov;57:441-8. doi: 10.1016/j.ejmech.2012.06.043. Epub 2012 Jul 16. Eur J Med Chem. 2012. PMID: 22840492

10

Species independence in brain tissue binding using brain homogenates.

Di L, Umland JP, Chang G, Huang Y, Lin Z, Scott DO, Troutman MD, Liston TE. Di L, et al. Drug Metab Dispos. 2011 Jul;39(7):1270-7. doi: 10.1124/dmd.111.038778. Epub 2011 Apr 7. Drug Metab Dispos. 2011. PMID: 21474681

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