Dudley DT - Search Results

1

Structures of human MAP kinase kinase 1 (MEK1) and MEK2 describe novel noncompetitive kinase inhibition.

Ohren JF, Chen H, Pavlovsky A, Whitehead C, Zhang E, Kuffa P, Yan C, McConnell P, Spessard C, Banotai C, Mueller WT, Delaney A, Omer C, Sebolt-Leopold J, Dudley DT, Leung IK, Flamme C, Warmus J, Kaufman M, Barrett S, Tecle H, Hasemann CA. Ohren JF, et al. Among authors: dudley dt. Nat Struct Mol Biol. 2004 Dec;11(12):1192-7. doi: 10.1038/nsmb859. Epub 2004 Nov 14. Nat Struct Mol Biol. 2004. PMID: 15543157

2

Identification of a novel mitogen-activated protein kinase kinase activation domain recognized by the inhibitor PD 184352.

Delaney AM, Printen JA, Chen H, Fauman EB, Dudley DT. Delaney AM, et al. Among authors: dudley dt. Mol Cell Biol. 2002 Nov;22(21):7593-602. doi: 10.1128/MCB.22.21.7593-7602.2002. Mol Cell Biol. 2002. PMID: 12370306 Free PMC article.

3

Central role of the MEK/ERK MAP kinase pathway in a mouse model of rheumatoid arthritis: potential proinflammatory mechanisms.

Thiel MJ, Schaefer CJ, Lesch ME, Mobley JL, Dudley DT, Tecle H, Barrett SD, Schrier DJ, Flory CM. Thiel MJ, et al. Among authors: dudley dt. Arthritis Rheum. 2007 Oct;56(10):3347-57. doi: 10.1002/art.22869. Arthritis Rheum. 2007. PMID: 17907188 Free article.

4

The discovery of the benzhydroxamate MEK inhibitors CI-1040 and PD 0325901.

Barrett SD, Bridges AJ, Dudley DT, Saltiel AR, Fergus JH, Flamme CM, Delaney AM, Kaufman M, LePage S, Leopold WR, Przybranowski SA, Sebolt-Leopold J, Van Becelaere K, Doherty AM, Kennedy RM, Marston D, Howard WA Jr, Smith Y, Warmus JS, Tecle H. Barrett SD, et al. Among authors: dudley dt. Bioorg Med Chem Lett. 2008 Dec 15;18(24):6501-4. doi: 10.1016/j.bmcl.2008.10.054. Epub 2008 Oct 15. Bioorg Med Chem Lett. 2008. PMID: 18952427

5

Blockade of the MAP kinase pathway suppresses growth of colon tumors in vivo.

Sebolt-Leopold JS, Dudley DT, Herrera R, Van Becelaere K, Wiland A, Gowan RC, Tecle H, Barrett SD, Bridges A, Przybranowski S, Leopold WR, Saltiel AR. Sebolt-Leopold JS, et al. Among authors: dudley dt. Nat Med. 1999 Jul;5(7):810-6. doi: 10.1038/10533. Nat Med. 1999. PMID: 10395327

6

Subtype selective muscarinic agonists: potential therapeutic agents for Alzheimer's disease.

Davis R, Raby C, Callahan MJ, Lipinski W, Schwarz R, Dudley DT, Lauffer D, Reece P, Jaen J, Tecle H. Davis R, et al. Among authors: dudley dt. Prog Brain Res. 1993;98:439-45. doi: 10.1016/s0079-6123(08)62430-9. Prog Brain Res. 1993. PMID: 8248534 Review. No abstract available.

7

PD98059 is an equipotent antagonist of the aryl hydrocarbon receptor and inhibitor of mitogen-activated protein kinase kinase.

Reiners JJ Jr, Lee JY, Clift RE, Dudley DT, Myrand SP. Reiners JJ Jr, et al. Among authors: dudley dt. Mol Pharmacol. 1998 Mar;53(3):438-45. doi: 10.1124/mol.53.3.438. Mol Pharmacol. 1998. PMID: 9495809

8

A synthetic inhibitor of the mitogen-activated protein kinase cascade.

Dudley DT, Pang L, Decker SJ, Bridges AJ, Saltiel AR. Dudley DT, et al. Proc Natl Acad Sci U S A. 1995 Aug 15;92(17):7686-9. doi: 10.1073/pnas.92.17.7686. Proc Natl Acad Sci U S A. 1995. PMID: 7644477 Free PMC article.

9

Design and synthesis of phenethyl benzo[1,4]oxazine-3-ones as potent inhibitors of PI3Kinasegamma.

Lanni TB Jr, Greene KL, Kolz CN, Para KS, Visnick M, Mobley JL, Dudley DT, Baginski TJ, Liimatta MB. Lanni TB Jr, et al. Among authors: dudley dt. Bioorg Med Chem Lett. 2007 Feb 1;17(3):756-60. doi: 10.1016/j.bmcl.2006.10.080. Epub 2006 Oct 28. Bioorg Med Chem Lett. 2007. PMID: 17095227

10

Characterization of angiotensin II (AT2) binding sites in R3T3 cells.

Dudley DT, Hubbell SE, Summerfelt RM. Dudley DT, et al. Mol Pharmacol. 1991 Sep;40(3):360-7. Mol Pharmacol. 1991. PMID: 1896025

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