Elzein E - Search Results

1

CVT-4325: a potent fatty acid oxidation inhibitor with favorable oral bioavailability.

Elzein E, Ibrahim P, Koltun DO, Rehder K, Shenk KD, Marquart TA, Jiang B, Li X, Natero R, Li Y, Nguyen M, Kerwar S, Chu N, Soohoo D, Hao J, Maydanik VY, Lustig DA, Zeng D, Leung K, Zablocki JA. Elzein E, et al. Bioorg Med Chem Lett. 2004 Dec 20;14(24):6017-21. doi: 10.1016/j.bmcl.2004.09.077. Bioorg Med Chem Lett. 2004. PMID: 15546720

2

New fatty acid oxidation inhibitors with increased potency lacking adverse metabolic and electrophysiological properties.

Koltun DO, Marquart TA, Shenk KD, Elzein E, Li Y, Nguyen M, Kerwar S, Zeng D, Chu N, Soohoo D, Hao J, Maydanik VY, Lustig DA, Ng KJ, Fraser H, Zablocki JA. Koltun DO, et al. Among authors: elzein e. Bioorg Med Chem Lett. 2004 Jan 19;14(2):549-52. doi: 10.1016/j.bmcl.2003.09.093. Bioorg Med Chem Lett. 2004. PMID: 14698201

3

Novel inhibitors of fatty acid oxidation as potential metabolic modulators.

Elzein E, Shenk K, Ibrahim P, Marquart T, Kerwar S, Meyer S, Ahmed H, Zeng D, Chu N, Soohoo D, Wong S, Leung K, Zablocki J. Elzein E, et al. Bioorg Med Chem Lett. 2004 Feb 23;14(4):973-7. doi: 10.1016/j.bmcl.2003.11.065. Bioorg Med Chem Lett. 2004. PMID: 15013004

4

Structure-affinity relationships of 5'-aromatic ethers and 5'-aromatic sulfides as partial A1 adenosine agonists, potential supraventricular anti-arrhythmic agents.

Morrison CF, Elzein E, Jiang B, Ibrahim PN, Marquart T, Palle V, Shenk KD, Varkhedkar V, Maa T, Wu L, Wu Y, Zeng D, Fong I, Lustig D, Leung K, Zablocki JA. Morrison CF, et al. Among authors: elzein e. Bioorg Med Chem Lett. 2004 Jul 16;14(14):3793-7. doi: 10.1016/j.bmcl.2004.04.096. Bioorg Med Chem Lett. 2004. PMID: 15203164

5

Novel 1,3-dipropyl-8-(1-heteroarylmethyl-1H-pyrazol-4-yl)-xanthine derivatives as high affinity and selective A2B adenosine receptor antagonists.

Elzein E, Kalla R, Li X, Perry T, Parkhill E, Palle V, Varkhedkar V, Gimbel A, Zeng D, Lustig D, Leung K, Zablocki J. Elzein E, et al. Bioorg Med Chem Lett. 2006 Jan 15;16(2):302-6. doi: 10.1016/j.bmcl.2005.10.002. Epub 2005 Nov 4. Bioorg Med Chem Lett. 2006. PMID: 16275090

6

Discovery of a novel A2B adenosine receptor antagonist as a clinical candidate for chronic inflammatory airway diseases.

Elzein E, Kalla RV, Li X, Perry T, Gimbel A, Zeng D, Lustig D, Leung K, Zablocki J. Elzein E, et al. J Med Chem. 2008 Apr 10;51(7):2267-78. doi: 10.1021/jm7014815. Epub 2008 Mar 6. J Med Chem. 2008. PMID: 18321039

7

Discovery of potent and selective inhibitors of calmodulin-dependent kinase II (CaMKII).

Koltun DO, Parkhill EQ, Kalla R, Perry TD, Elzein E, Li X, Simonovich SP, Ziebenhaus C, Hansen TR, Marchand B, Hung WK, Lagpacan L, Hung M, Aoyama RG, Murray BP, Perry JK, Somoza JR, Villaseñor AG, Pagratis N, Zablocki JA. Koltun DO, et al. Among authors: elzein e. Bioorg Med Chem Lett. 2018 Feb 1;28(3):541-546. doi: 10.1016/j.bmcl.2017.10.040. Epub 2017 Oct 20. Bioorg Med Chem Lett. 2018. PMID: 29254643

8

2-Pyrazolyl-N(6)-substituted adenosine derivatives as high affinity and selective adenosine A(3) receptor agonists.

Elzein E, Palle V, Wu Y, Maa T, Zeng D, Zablocki J. Elzein E, et al. J Med Chem. 2004 Sep 9;47(19):4766-73. doi: 10.1021/jm049682h. J Med Chem. 2004. PMID: 15341491

9

Novel 1,3-disubstituted 8-(1-benzyl-1H-pyrazol-4-yl) xanthines: high affinity and selective A2B adenosine receptor antagonists.

Kalla RV, Elzein E, Perry T, Li X, Palle V, Varkhedkar V, Gimbel A, Maa T, Zeng D, Zablocki J. Kalla RV, et al. Among authors: elzein e. J Med Chem. 2006 Jun 15;49(12):3682-92. doi: 10.1021/jm051268+. J Med Chem. 2006. PMID: 16759111

10

N6-Cycloalkyl-2-substituted adenosine derivatives as selective, high affinity adenosine A1 receptor agonists.

Elzein E, Kalla R, Li X, Perry T, Marquart T, Micklatcher M, Li Y, Wu Y, Zeng D, Zablocki J. Elzein E, et al. Bioorg Med Chem Lett. 2007 Jan 1;17(1):161-6. doi: 10.1016/j.bmcl.2006.09.065. Epub 2006 Oct 11. Bioorg Med Chem Lett. 2007. PMID: 17045477

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