Degen JL - Search Results

1

Fibrin(ogen)-alpha M beta 2 interactions regulate leukocyte function and innate immunity in vivo.

Flick MJ, Du X, Degen JL. Flick MJ, et al. Among authors: degen jl. Exp Biol Med (Maywood). 2004 Dec;229(11):1105-10. doi: 10.1177/153537020422901104. Exp Biol Med (Maywood). 2004. PMID: 15564436 Review.

2

Leukocyte engagement of fibrin(ogen) via the integrin receptor alphaMbeta2/Mac-1 is critical for host inflammatory response in vivo.

Flick MJ, Du X, Witte DP, Jirousková M, Soloviev DA, Busuttil SJ, Plow EF, Degen JL. Flick MJ, et al. Among authors: degen jl. J Clin Invest. 2004 Jun;113(11):1596-606. doi: 10.1172/JCI20741. J Clin Invest. 2004. PMID: 15173886 Free PMC article.

3

Platelets and fibrin(ogen) increase metastatic potential by impeding natural killer cell-mediated elimination of tumor cells.

Palumbo JS, Talmage KE, Massari JV, La Jeunesse CM, Flick MJ, Kombrinck KW, Jirousková M, Degen JL. Palumbo JS, et al. Among authors: degen jl. Blood. 2005 Jan 1;105(1):178-85. doi: 10.1182/blood-2004-06-2272. Epub 2004 Sep 14. Blood. 2005. PMID: 15367435 Free article.

4

Fibrin(ogen) exacerbates inflammatory joint disease through a mechanism linked to the integrin alphaMbeta2 binding motif.

Flick MJ, LaJeunesse CM, Talmage KE, Witte DP, Palumbo JS, Pinkerton MD, Thornton S, Degen JL. Flick MJ, et al. Among authors: degen jl. J Clin Invest. 2007 Nov;117(11):3224-35. doi: 10.1172/JCI30134. J Clin Invest. 2007. PMID: 17932565 Free PMC article.

5

Genetic elimination of the binding motif on fibrinogen for the S. aureus virulence factor ClfA improves host survival in septicemia.

Flick MJ, Du X, Prasad JM, Raghu H, Palumbo JS, Smeds E, Höök M, Degen JL. Flick MJ, et al. Among authors: degen jl. Blood. 2013 Mar 7;121(10):1783-94. doi: 10.1182/blood-2012-09-453894. Epub 2013 Jan 8. Blood. 2013. PMID: 23299312 Free PMC article.

6

The fibrin-derived gamma377-395 peptide inhibits microglia activation and suppresses relapsing paralysis in central nervous system autoimmune disease.

Adams RA, Bauer J, Flick MJ, Sikorski SL, Nuriel T, Lassmann H, Degen JL, Akassoglou K. Adams RA, et al. Among authors: degen jl. J Exp Med. 2007 Mar 19;204(3):571-82. doi: 10.1084/jem.20061931. Epub 2007 Mar 5. J Exp Med. 2007. PMID: 17339406 Free PMC article.

7

Tumor cell-associated tissue factor and circulating hemostatic factors cooperate to increase metastatic potential through natural killer cell-dependent and-independent mechanisms.

Palumbo JS, Talmage KE, Massari JV, La Jeunesse CM, Flick MJ, Kombrinck KW, Hu Z, Barney KA, Degen JL. Palumbo JS, et al. Among authors: degen jl. Blood. 2007 Jul 1;110(1):133-41. doi: 10.1182/blood-2007-01-065995. Epub 2007 Mar 19. Blood. 2007. PMID: 17371949 Free PMC article.

8

Genetic elimination of prothrombin in adult mice is not compatible with survival and results in spontaneous hemorrhagic events in both heart and brain.

Mullins ES, Kombrinck KW, Talmage KE, Shaw MA, Witte DP, Ullman JM, Degen SJ, Sun W, Flick MJ, Degen JL. Mullins ES, et al. Among authors: degen sj, degen jl. Blood. 2009 Jan 15;113(3):696-704. doi: 10.1182/blood-2008-07-169003. Epub 2008 Oct 16. Blood. 2009. PMID: 18927430 Free PMC article.

9

Thrombomodulin is a determinant of metastasis through a mechanism linked to the thrombin binding domain but not the lectin-like domain.

Horowitz NA, Blevins EA, Miller WM, Perry AR, Talmage KE, Mullins ES, Flick MJ, Queiroz KC, Shi K, Spek CA, Conway EM, Monia BP, Weiler H, Degen JL, Palumbo JS. Horowitz NA, et al. Among authors: degen jl. Blood. 2011 Sep 8;118(10):2889-95. doi: 10.1182/blood-2011-03-341222. Epub 2011 Jul 25. Blood. 2011. PMID: 21788337 Free PMC article.

10

Plasminogen is a joint-specific positive or negative determinant of arthritis pathogenesis in mice.

Raghu H, Jone A, Cruz C, Rewerts CL, Frederick MD, Thornton S, Degen JL, Flick MJ. Raghu H, et al. Among authors: degen jl. Arthritis Rheumatol. 2014 Jun;66(6):1504-16. doi: 10.1002/art.38402. Arthritis Rheumatol. 2014. PMID: 24574269 Free PMC article.

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