Makara GM - Search Results

1

Identification of a small molecule nonpeptide active site beta-secretase inhibitor that displays a nontraditional binding mode for aspartyl proteases.

Coburn CA, Stachel SJ, Li YM, Rush DM, Steele TG, Chen-Dodson E, Holloway MK, Xu M, Huang Q, Lai MT, DiMuzio J, Crouthamel MC, Shi XP, Sardana V, Chen Z, Munshi S, Kuo L, Makara GM, Annis DA, Tadikonda PK, Nash HM, Vacca JP, Wang T. Coburn CA, et al. Among authors: makara gm. J Med Chem. 2004 Dec 2;47(25):6117-9. doi: 10.1021/jm049388p. J Med Chem. 2004. PMID: 15566281

2

A reagent-based strategy for the design of large combinatorial libraries: a preliminary experimental validation.

Makara GM, Nash H, Zheng Z, Orminati JP, Wintner EA. Makara GM, et al. Mol Divers. 2003;7(1):3-14. doi: 10.1023/b:modi.0000006537.06541.8a. Mol Divers. 2003. PMID: 14768899

3

Synthesis and modeling studies with monocyclic analogues of mycophenolic acid.

Anderson WK, Boehm TL, Makara GM, Swann RT. Anderson WK, et al. Among authors: makara gm. J Med Chem. 1996 Jan 5;39(1):46-55. doi: 10.1021/jm9501339. J Med Chem. 1996. PMID: 8568826

4

Nuclear magnetic resonance and molecular modeling study on mycophenolic acid: implications for binding to inosine monophosphate dehydrogenase.

Makara GM, Keserû GM, Kajtár-Peredy M, Anderson WK. Makara GM, et al. J Med Chem. 1996 Mar 15;39(6):1236-42. doi: 10.1021/jm950600m. J Med Chem. 1996. PMID: 8632430

5

On sampling of fragment space.

Makara GM. Makara GM. J Med Chem. 2007 Jul 12;50(14):3214-21. doi: 10.1021/jm0700316. Epub 2007 Jun 14. J Med Chem. 2007. PMID: 17567120

6

Synthesis, molecular modeling, and evaluation of nonphenolic indole analogs of mycophenolic acid.

El-Araby ME, Bernacki RJ, Makara GM, Pera PJ, Anderson WK. El-Araby ME, et al. Among authors: makara gm. Bioorg Med Chem. 2004 Jun 1;12(11):2867-79. doi: 10.1016/j.bmc.2004.03.048. Bioorg Med Chem. 2004. PMID: 15142547

7

On the conformation of tiazofurin analogues.

Makara GM, Keserû GM. Makara GM, et al. J Med Chem. 1997 Dec 5;40(25):4154-9. doi: 10.1021/jm970129s. J Med Chem. 1997. PMID: 9406604

8

Measuring molecular similarity and diversity: total pharmacophore diversity.

Makara GM. Makara GM. J Med Chem. 2001 Oct 25;44(22):3563-71. doi: 10.1021/jm010036h. J Med Chem. 2001. PMID: 11606120

9

Versatile solid-phase synthesis of trisubstituted 1H-pyrido[2,3-d]pyrimidin-4-ones and related heterocycles.

Schell P, Richards MP, Hanson K, Berk SC, Makara GM. Schell P, et al. Among authors: makara gm. J Comb Chem. 2005 Jan-Feb;7(1):96-8. doi: 10.1021/cc049921m. J Comb Chem. 2005. PMID: 15638487

10

Improving success rates for lead generation using affinity binding technologies.

Makara GM, Athanasopoulos J. Makara GM, et al. Curr Opin Biotechnol. 2005 Dec;16(6):666-73. doi: 10.1016/j.copbio.2005.10.007. Epub 2005 Oct 28. Curr Opin Biotechnol. 2005. PMID: 16257522 Free PMC article. Review.

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