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Page 1
The discovery of orally active triaminotriazine aniline amides as inhibitors of p38 MAP kinase.
Leftheris K, Ahmed G, Chan R, Dyckman AJ, Hussain Z, Ho K, Hynes J Jr, Letourneau J, Li W, Lin S, Metzger A, Moriarty KJ, Riviello C, Shimshock Y, Wen J, Wityak J, Wrobleski ST, Wu H, Wu J, Desai M, Gillooly KM, Lin TH, Loo D, McIntyre KW, Pitt S, Shen DR, Shuster DJ, Zhang R, Diller D, Doweyko A, Sack J, Baldwin J, Barrish J, Dodd J, Henderson I, Kanner S, Schieven GL, Webb M. Leftheris K, et al. Among authors: letourneau j. J Med Chem. 2004 Dec 2;47(25):6283-91. doi: 10.1021/jm049521d. J Med Chem. 2004. PMID: 15566298
2-Benzimidazolyl-9-(chroman-4-yl)-purinone derivatives as JAK3 inhibitors.
Cole AG, Bohnstedt AC, Paradkar V, Kingsbury C, Quintero JG, Park H, Lu Y, You M, Neagu I, Diller DJ, Letourneau JJ, Shao Y, James RA, Riviello CM, Ho KK, Lin TH, Wang B, Appell KC, Sills M, Quadros E, Kimble EF, Ohlmeyer MH, Webb ML. Cole AG, et al. Among authors: letourneau jj. Bioorg Med Chem Lett. 2009 Dec 1;19(23):6788-92. doi: 10.1016/j.bmcl.2009.09.080. Epub 2009 Sep 25. Bioorg Med Chem Lett. 2009. PMID: 19836234
Synthesis and SAR studies of novel 2-(4-oxo-2-aryl-quinazolin-3(4H)-yl)acetamide vasopressin V1b receptor antagonists.
Napier SE, Letourneau JJ, Ansari N, Auld DS, Baker J, Best S, Campbell-Wan L, Chan JH, Craighead M, Desai H, Goan KA, Ho KK, Hulskotte EG, MacSweeney CP, Milne R, Morphy JR, Neagu I, Ohlmeyer MH, Peeters AW, Presland J, Riviello C, Ruigt GS, Thomson FJ, Zanetakos HA, Zhao J, Webb ML. Napier SE, et al. Among authors: letourneau jj. Bioorg Med Chem Lett. 2011 Mar 15;21(6):1871-5. doi: 10.1016/j.bmcl.2010.12.081. Epub 2010 Dec 21. Bioorg Med Chem Lett. 2011. PMID: 21353540
Synthesis and SAR studies of novel 2-(6-aminomethylaryl-2-aryl-4-oxo-quinazolin-3(4H)-yl)acetamide vasopressin V1b receptor antagonists.
Napier SE, Letourneau JJ, Ansari N, Auld DS, Baker J, Best S, Campbell-Wan L, Chan R, Craighead M, Desai H, Ho KK, MacSweeney C, Milne R, Richard Morphy J, Neagu I, Ohlmeyer MH, Pick J, Presland J, Riviello C, Zanetakos HA, Zhao J, Webb ML. Napier SE, et al. Among authors: letourneau jj. Bioorg Med Chem Lett. 2011 Jun 15;21(12):3813-7. doi: 10.1016/j.bmcl.2011.04.022. Epub 2011 Apr 13. Bioorg Med Chem Lett. 2011. PMID: 21596563
Identification and hit-to-lead optimization of a novel class of CB1 antagonists.
Letourneau JJ, Jokiel P, Olson J, Riviello CM, Ho KK, McAleer L, Yang J, Swanson RN, Baker J, Cowley P, Edwards D, Ward N, Ohlmeyer MH, Webb ML. Letourneau JJ, et al. Bioorg Med Chem Lett. 2010 Sep 15;20(18):5449-53. doi: 10.1016/j.bmcl.2010.07.091. Epub 2010 Jul 25. Bioorg Med Chem Lett. 2010. PMID: 20719511
Treatment of Clostridium difficile Infection with a Small-Molecule Inhibitor of Toxin UDP-Glucose Hydrolysis Activity.
Stroke IL, Letourneau JJ, Miller TE, Xu Y, Pechik I, Savoly DR, Ma L, Sturzenbecker LJ, Sabalski J, Stein PD, Webb ML, Hilbert DW. Stroke IL, et al. Among authors: letourneau jj. Antimicrob Agents Chemother. 2018 Apr 26;62(5):e00107-18. doi: 10.1128/AAC.00107-18. Print 2018 May. Antimicrob Agents Chemother. 2018. PMID: 29483125 Free PMC article.
232 results