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p38alpha mitogen-activated protein kinase plays a critical role in cardiomyocyte survival but not in cardiac hypertrophic growth in response to pressure overload.
Nishida K, Yamaguchi O, Hirotani S, Hikoso S, Higuchi Y, Watanabe T, Takeda T, Osuka S, Morita T, Kondoh G, Uno Y, Kashiwase K, Taniike M, Nakai A, Matsumura Y, Miyazaki J, Sudo T, Hongo K, Kusakari Y, Kurihara S, Chien KR, Takeda J, Hori M, Otsu K. Nishida K, et al. Among authors: hori m. Mol Cell Biol. 2004 Dec;24(24):10611-20. doi: 10.1128/MCB.24.24.10611-10620.2004. Mol Cell Biol. 2004. PMID: 15572667 Free PMC article.
Cardiac-specific disruption of the c-raf-1 gene induces cardiac dysfunction and apoptosis.
Yamaguchi O, Watanabe T, Nishida K, Kashiwase K, Higuchi Y, Takeda T, Hikoso S, Hirotani S, Asahi M, Taniike M, Nakai A, Tsujimoto I, Matsumura Y, Miyazaki J, Chien KR, Matsuzawa A, Sadamitsu C, Ichijo H, Baccarini M, Hori M, Otsu K. Yamaguchi O, et al. Among authors: hori m. J Clin Invest. 2004 Oct;114(7):937-43. doi: 10.1172/JCI20317. J Clin Invest. 2004. PMID: 15467832 Free PMC article.
Pressure overload induces cardiac dysfunction and dilation in signal transducer and activator of transcription 6-deficient mice.
Hikoso S, Yamaguchi O, Higuchi Y, Hirotani S, Takeda T, Kashiwase K, Watanabe T, Taniike M, Tsujimoto I, Asahi M, Matsumura Y, Nishida K, Nakajima H, Akira S, Hori M, Otsu K. Hikoso S, et al. Among authors: hori m. Circulation. 2004 Oct 26;110(17):2631-7. doi: 10.1161/01.CIR.0000146798.70980.9A. Epub 2004 Oct 18. Circulation. 2004. PMID: 15492321
CaMKII activates ASK1 and NF-kappaB to induce cardiomyocyte hypertrophy.
Kashiwase K, Higuchi Y, Hirotani S, Yamaguchi O, Hikoso S, Takeda T, Watanabe T, Taniike M, Nakai A, Tsujimoto I, Matsumura Y, Ueno H, Nishida K, Hori M, Otsu K. Kashiwase K, et al. Among authors: hori m. Biochem Biophys Res Commun. 2005 Feb 4;327(1):136-42. doi: 10.1016/j.bbrc.2004.12.002. Biochem Biophys Res Commun. 2005. PMID: 15629441
The I{kappa}B kinase {beta}/nuclear factor {kappa}B signaling pathway protects the heart from hemodynamic stress mediated by the regulation of manganese superoxide dismutase expression.
Hikoso S, Yamaguchi O, Nakano Y, Takeda T, Omiya S, Mizote I, Taneike M, Oka T, Tamai T, Oyabu J, Uno Y, Matsumura Y, Nishida K, Suzuki K, Kogo M, Hori M, Otsu K. Hikoso S, et al. Among authors: hori m. Circ Res. 2009 Jul 2;105(1):70-9. doi: 10.1161/CIRCRESAHA.108.193318. Epub 2009 May 28. Circ Res. 2009. PMID: 19478205
Activation of MTK1/MEKK4 induces cardiomyocyte death and heart failure.
Mizote I, Yamaguchi O, Hikoso S, Takeda T, Taneike M, Oka T, Tamai T, Oyabu J, Matsumura Y, Nishida K, Komuro I, Hori M, Otsu K. Mizote I, et al. Among authors: hori m. J Mol Cell Cardiol. 2010 Feb;48(2):302-9. doi: 10.1016/j.yjmcc.2009.10.010. Epub 2009 Oct 20. J Mol Cell Cardiol. 2010. PMID: 19850048
3,237 results