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p38alpha mitogen-activated protein kinase plays a critical role in cardiomyocyte survival but not in cardiac hypertrophic growth in response to pressure overload.
Nishida K, Yamaguchi O, Hirotani S, Hikoso S, Higuchi Y, Watanabe T, Takeda T, Osuka S, Morita T, Kondoh G, Uno Y, Kashiwase K, Taniike M, Nakai A, Matsumura Y, Miyazaki J, Sudo T, Hongo K, Kusakari Y, Kurihara S, Chien KR, Takeda J, Hori M, Otsu K. Nishida K, et al. Among authors: uno y. Mol Cell Biol. 2004 Dec;24(24):10611-20. doi: 10.1128/MCB.24.24.10611-10620.2004. Mol Cell Biol. 2004. PMID: 15572667 Free PMC article.
The I{kappa}B kinase {beta}/nuclear factor {kappa}B signaling pathway protects the heart from hemodynamic stress mediated by the regulation of manganese superoxide dismutase expression.
Hikoso S, Yamaguchi O, Nakano Y, Takeda T, Omiya S, Mizote I, Taneike M, Oka T, Tamai T, Oyabu J, Uno Y, Matsumura Y, Nishida K, Suzuki K, Kogo M, Hori M, Otsu K. Hikoso S, et al. Among authors: uno y. Circ Res. 2009 Jul 2;105(1):70-9. doi: 10.1161/CIRCRESAHA.108.193318. Epub 2009 May 28. Circ Res. 2009. PMID: 19478205
Rheb (Ras homologue enriched in brain)-dependent mammalian target of rapamycin complex 1 (mTORC1) activation becomes indispensable for cardiac hypertrophic growth after early postnatal period.
Tamai T, Yamaguchi O, Hikoso S, Takeda T, Taneike M, Oka T, Oyabu J, Murakawa T, Nakayama H, Uno Y, Horie K, Nishida K, Sonenberg N, Shah AM, Takeda J, Komuro I, Otsu K. Tamai T, et al. Among authors: uno y. J Biol Chem. 2013 Apr 5;288(14):10176-10187. doi: 10.1074/jbc.M112.423640. Epub 2013 Feb 20. J Biol Chem. 2013. PMID: 23426372 Free PMC article.
FKBP8 protects the heart from hemodynamic stress by preventing the accumulation of misfolded proteins and endoplasmic reticulum-associated apoptosis in mice.
Misaka T, Murakawa T, Nishida K, Omori Y, Taneike M, Omiya S, Molenaar C, Uno Y, Yamaguchi O, Takeda J, Shah AM, Otsu K. Misaka T, et al. Among authors: uno y. J Mol Cell Cardiol. 2018 Jan;114:93-104. doi: 10.1016/j.yjmcc.2017.11.004. Epub 2017 Nov 10. J Mol Cell Cardiol. 2018. PMID: 29129702 Free PMC article.
CLICK: one-step generation of conditional knockout mice.
Miyasaka Y, Uno Y, Yoshimi K, Kunihiro Y, Yoshimura T, Tanaka T, Ishikubo H, Hiraoka Y, Takemoto N, Tanaka T, Ooguchi Y, Skehel P, Aida T, Takeda J, Mashimo T. Miyasaka Y, et al. Among authors: uno y. BMC Genomics. 2018 May 2;19(1):318. doi: 10.1186/s12864-018-4713-y. BMC Genomics. 2018. PMID: 29720086 Free PMC article.
719 results