Browne K - Search Results

1

Calcium-dependent plasma membrane binding and cell lysis by perforin are mediated through its C2 domain: A critical role for aspartate residues 429, 435, 483, and 485 but not 491.

Voskoboinik I, Thia MC, Fletcher J, Ciccone A, Browne K, Smyth MJ, Trapani JA. Voskoboinik I, et al. Among authors: browne k. J Biol Chem. 2005 Mar 4;280(9):8426-34. doi: 10.1074/jbc.M413303200. Epub 2004 Dec 2. J Biol Chem. 2005. PMID: 15576364 Free article.

2

The functional basis for hemophagocytic lymphohistiocytosis in a patient with co-inherited missense mutations in the perforin (PFN1) gene.

Voskoboinik I, Thia MC, De Bono A, Browne K, Cretney E, Jackson JT, Darcy PK, Jane SM, Smyth MJ, Trapani JA. Voskoboinik I, et al. Among authors: browne k. J Exp Med. 2004 Sep 20;200(6):811-6. doi: 10.1084/jem.20040776. Epub 2004 Sep 14. J Exp Med. 2004. PMID: 15365097 Free PMC article.

3

Granzyme M mediates a novel form of perforin-dependent cell death.

Kelly JM, Waterhouse NJ, Cretney E, Browne KA, Ellis S, Trapani JA, Smyth MJ. Kelly JM, et al. J Biol Chem. 2004 May 21;279(21):22236-42. doi: 10.1074/jbc.M401670200. Epub 2004 Mar 17. J Biol Chem. 2004. PMID: 15028722 Free article.

4

Dihydrofuro[3,4-c]pyridinones as inhibitors of the cytolytic effects of the pore-forming glycoprotein perforin.

Lena G, Trapani JA, Sutton VR, Ciccone A, Browne KA, Smyth MJ, Denny WA, Spicer JA. Lena G, et al. J Med Chem. 2008 Dec 11;51(23):7614-24. doi: 10.1021/jm801063n. J Med Chem. 2008. PMID: 19007200

5

The molecular basis for perforin oligomerization and transmembrane pore assembly.

Baran K, Dunstone M, Chia J, Ciccone A, Browne KA, Clarke CJ, Lukoyanova N, Saibil H, Whisstock JC, Voskoboinik I, Trapani JA. Baran K, et al. Among authors: browne ka. Immunity. 2009 May;30(5):684-95. doi: 10.1016/j.immuni.2009.03.016. Epub 2009 May 14. Immunity. 2009. PMID: 19446473 Free article.

6

Exploration of a series of 5-arylidene-2-thioxoimidazolidin-4-ones as inhibitors of the cytolytic protein perforin.

Spicer JA, Lena G, Lyons DM, Huttunen KM, Miller CK, O'Connor PD, Bull M, Helsby N, Jamieson SM, Denny WA, Ciccone A, Browne KA, Lopez JA, Rudd-Schmidt J, Voskoboinik I, Trapani JA. Spicer JA, et al. Among authors: browne ka. J Med Chem. 2013 Dec 12;56(23):9542-55. doi: 10.1021/jm401604x. Epub 2013 Nov 19. J Med Chem. 2013. PMID: 24195776 Free PMC article.

7

Substituted arylsulphonamides as inhibitors of perforin-mediated lysis.

Spicer JA, Miller CK, O'Connor PD, Jose J, Huttunen KM, Jaiswal JK, Denny WA, Akhlaghi H, Browne KA, Trapani JA. Spicer JA, et al. Among authors: browne ka. Eur J Med Chem. 2017 Sep 8;137:139-155. doi: 10.1016/j.ejmech.2017.05.048. Epub 2017 May 26. Eur J Med Chem. 2017. PMID: 28582670 Free PMC article.

8

Filamin (280-kDa actin-binding protein) is a caspase substrate and is also cleaved directly by the cytotoxic T lymphocyte protease granzyme B during apoptosis.

Browne KA, Johnstone RW, Jans DA, Trapani JA. Browne KA, et al. J Biol Chem. 2000 Dec 15;275(50):39262-6. doi: 10.1074/jbc.C000622200. J Biol Chem. 2000. PMID: 11050075 Free article.

9

Measuring cell death mediated by cytotoxic lymphocytes or their granule effector molecules.

Sutton VR, Waterhouse NJ, Baran K, Browne K, Voskoboinik I, Trapani JA. Sutton VR, et al. Among authors: browne k. Methods. 2008 Mar;44(3):241-9. doi: 10.1016/j.ymeth.2007.11.011. Methods. 2008. PMID: 18314055 Review.

10

A clathrin/dynamin- and mannose-6-phosphate receptor-independent pathway for granzyme B-induced cell death.

Trapani JA, Sutton VR, Thia KY, Li YQ, Froelich CJ, Jans DA, Sandrin MS, Browne KA. Trapani JA, et al. J Cell Biol. 2003 Jan 20;160(2):223-33. doi: 10.1083/jcb.200210150. Epub 2003 Jan 21. J Cell Biol. 2003. PMID: 12538642 Free PMC article.

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