Ciccone A - Search Results

1

Calcium-dependent plasma membrane binding and cell lysis by perforin are mediated through its C2 domain: A critical role for aspartate residues 429, 435, 483, and 485 but not 491.

Voskoboinik I, Thia MC, Fletcher J, Ciccone A, Browne K, Smyth MJ, Trapani JA. Voskoboinik I, et al. Among authors: ciccone a. J Biol Chem. 2005 Mar 4;280(9):8426-34. doi: 10.1074/jbc.M413303200. Epub 2004 Dec 2. J Biol Chem. 2005. PMID: 15576364 Free article.

2

Cytotoxic T lymphocytes from cathepsin B-deficient mice survive normally in vitro and in vivo after encountering and killing target cells.

Baran K, Ciccone A, Peters C, Yagita H, Bird PI, Villadangos JA, Trapani JA. Baran K, et al. Among authors: ciccone a. J Biol Chem. 2006 Oct 13;281(41):30485-91. doi: 10.1074/jbc.M602007200. Epub 2006 Aug 16. J Biol Chem. 2006. PMID: 16914553 Free article.

3

Perforin activity and immune homeostasis: the common A91V polymorphism in perforin results in both presynaptic and postsynaptic defects in function.

Voskoboinik I, Sutton VR, Ciccone A, House CM, Chia J, Darcy PK, Yagita H, Trapani JA. Voskoboinik I, et al. Among authors: ciccone a. Blood. 2007 Aug 15;110(4):1184-90. doi: 10.1182/blood-2007-02-072850. Epub 2007 May 2. Blood. 2007. PMID: 17475905 Free article.

4

Dihydrofuro[3,4-c]pyridinones as inhibitors of the cytolytic effects of the pore-forming glycoprotein perforin.

Lena G, Trapani JA, Sutton VR, Ciccone A, Browne KA, Smyth MJ, Denny WA, Spicer JA. Lena G, et al. Among authors: ciccone a. J Med Chem. 2008 Dec 11;51(23):7614-24. doi: 10.1021/jm801063n. J Med Chem. 2008. PMID: 19007200

5

The molecular basis for perforin oligomerization and transmembrane pore assembly.

Baran K, Dunstone M, Chia J, Ciccone A, Browne KA, Clarke CJ, Lukoyanova N, Saibil H, Whisstock JC, Voskoboinik I, Trapani JA. Baran K, et al. Among authors: ciccone a. Immunity. 2009 May;30(5):684-95. doi: 10.1016/j.immuni.2009.03.016. Epub 2009 May 14. Immunity. 2009. PMID: 19446473 Free article.

6

Exploration of a series of 5-arylidene-2-thioxoimidazolidin-4-ones as inhibitors of the cytolytic protein perforin.

Spicer JA, Lena G, Lyons DM, Huttunen KM, Miller CK, O'Connor PD, Bull M, Helsby N, Jamieson SM, Denny WA, Ciccone A, Browne KA, Lopez JA, Rudd-Schmidt J, Voskoboinik I, Trapani JA. Spicer JA, et al. Among authors: ciccone a. J Med Chem. 2013 Dec 12;56(23):9542-55. doi: 10.1021/jm401604x. Epub 2013 Nov 19. J Med Chem. 2013. PMID: 24195776 Free PMC article.

7

Cytotoxic T lymphocyte-induced killing in the absence of granzymes A and B is unique and distinct from both apoptosis and perforin-dependent lysis.

Waterhouse NJ, Sutton VR, Sedelies KA, Ciccone A, Jenkins M, Turner SJ, Bird PI, Trapani JA. Waterhouse NJ, et al. Among authors: ciccone a. J Cell Biol. 2006 Apr 10;173(1):133-44. doi: 10.1083/jcb.200510072. J Cell Biol. 2006. PMID: 16606695 Free PMC article.

8

Residual active granzyme B in cathepsin C-null lymphocytes is sufficient for perforin-dependent target cell apoptosis.

Sutton VR, Waterhouse NJ, Browne KA, Sedelies K, Ciccone A, Anthony D, Koskinen A, Mullbacher A, Trapani JA. Sutton VR, et al. Among authors: ciccone a. J Cell Biol. 2007 Feb 12;176(4):425-33. doi: 10.1083/jcb.200609077. Epub 2007 Feb 5. J Cell Biol. 2007. PMID: 17283185 Free PMC article.

9

The structural basis for membrane binding and pore formation by lymphocyte perforin.

Law RH, Lukoyanova N, Voskoboinik I, Caradoc-Davies TT, Baran K, Dunstone MA, D'Angelo ME, Orlova EV, Coulibaly F, Verschoor S, Browne KA, Ciccone A, Kuiper MJ, Bird PI, Trapani JA, Saibil HR, Whisstock JC. Law RH, et al. Among authors: ciccone a. Nature. 2010 Nov 18;468(7322):447-51. doi: 10.1038/nature09518. Epub 2010 Oct 31. Nature. 2010. PMID: 21037563

10

Protection from endogenous perforin: glycans and the C terminus regulate exocytic trafficking in cytotoxic lymphocytes.

Brennan AJ, Chia J, Browne KA, Ciccone A, Ellis S, Lopez JA, Susanto O, Verschoor S, Yagita H, Whisstock JC, Trapani JA, Voskoboinik I. Brennan AJ, et al. Among authors: ciccone a. Immunity. 2011 Jun 24;34(6):879-92. doi: 10.1016/j.immuni.2011.04.007. Epub 2011 Jun 9. Immunity. 2011. PMID: 21658975 Free article.

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