Zhang H - Search Results

1

Design and synthesis of o-trifluoromethylbiphenyl substituted 2-amino-nicotinonitriles as inhibitors of farnesyltransferase.

Wang GT, Wang X, Wang W, Hasvold LA, Sullivan G, Hutchins CW, O'Conner S, Gentiles R, Sowin T, Cohen J, Gu WZ, Zhang H, Rosenberg SH, Sham HL. Wang GT, et al. Among authors: zhang h. Bioorg Med Chem Lett. 2005 Jan 3;15(1):153-8. doi: 10.1016/j.bmcl.2004.10.014. Bioorg Med Chem Lett. 2005. PMID: 15582430

2

Synthesis and biological evaluation of 4-[3-biphenyl-2-yl-1-hydroxy-1-(3-methyl-3H-imidazol-4-yl)-prop-2-ynyl]-1-yl-benzonitrile as novel farnesyltransferase inhibitor.

Lin NH, Wang L, Cohen J, Gu WZ, Frost D, Zhang H, Rosenberg S, Sham H. Lin NH, et al. Among authors: zhang h. Bioorg Med Chem Lett. 2003 Apr 7;13(7):1293-6. doi: 10.1016/s0960-894x(03)00122-7. Bioorg Med Chem Lett. 2003. PMID: 12657267

3

Aryl tetrahydropyridine inhibitors of farnesyltransferase: glycine, phenylalanine and histidine derivatives.

Gwaltney SL 2nd, O'Connor SJ, Nelson LT, Sullivan GM, Imade H, Wang W, Hasvold L, Li Q, Cohen J, Gu WZ, Tahir SK, Bauch J, Marsh K, Ng SC, Frost DJ, Zhang H, Muchmore S, Jakob CG, Stoll V, Hutchins C, Rosenberg SH, Sham HL. Gwaltney SL 2nd, et al. Among authors: zhang h. Bioorg Med Chem Lett. 2003 Apr 7;13(7):1359-62. doi: 10.1016/s0960-894x(03)00095-7. Bioorg Med Chem Lett. 2003. PMID: 12657282

4

Aryl tetrahydropyridine inhibitors of farnesyltransferase: bioavailable analogues with improved cellular potency.

Gwaltney SL 2nd, O'Connor SJ, Nelson LT, Sullivan GM, Imade H, Wang W, Hasvold L, Li Q, Cohen J, Gu WZ, Tahir SK, Bauch J, Marsh K, Ng SC, Frost DJ, Zhang H, Muchmore S, Jakob CG, Stoll V, Hutchins C, Rosenberg SH, Sham HL. Gwaltney SL 2nd, et al. Among authors: zhang h. Bioorg Med Chem Lett. 2003 Apr 7;13(7):1363-6. doi: 10.1016/s0960-894x(03)00094-5. Bioorg Med Chem Lett. 2003. PMID: 12657283

5

Discovery of potent imidazole and cyanophenyl containing farnesyltransferase inhibitors with improved oral bioavailability.

Tong Y, Lin NH, Wang L, Hasvold L, Wang W, Leonard N, Li T, Li Q, Cohen J, Gu WZ, Zhang H, Stoll V, Bauch J, Marsh K, Rosenberg SH, Sham HL. Tong Y, et al. Among authors: zhang h. Bioorg Med Chem Lett. 2003 May 5;13(9):1571-4. doi: 10.1016/s0960-894x(03)00195-1. Bioorg Med Chem Lett. 2003. PMID: 12699757

6

Synthesis and biological evaluation of 4-[(3-methyl-3H-imidazol-4-yl)-(2-phenylethynyl-benzyloxy)-methyl]-benzonitrile as novel farnesyltransferase inhibitor.

Lin NH, Wang L, Cohen J, Gu WZ, Frost D, Zhang H, Rosenberg S, Sham H. Lin NH, et al. Among authors: zhang h. Bioorg Med Chem Lett. 2003 Nov 3;13(21):3821-5. doi: 10.1016/j.bmcl.2003.07.006. Bioorg Med Chem Lett. 2003. PMID: 14552788

7

Pyridone-containing farnesyltransferase inhibitors: synthesis and biological evaluation.

Hasvold LA, Wang W, Gwaltney SL 2nd, Rockway TW, Nelson LT, Mantei RA, Fakhoury SA, Sullivan GM, Li Q, Lin NH, Wang L, Zhang H, Cohen J, Gu WZ, Marsh K, Bauch J, Rosenberg S, Sham HL. Hasvold LA, et al. Among authors: zhang h. Bioorg Med Chem Lett. 2003 Nov 17;13(22):4001-5. doi: 10.1016/j.bmcl.2003.08.058. Bioorg Med Chem Lett. 2003. PMID: 14592494

8

Design, synthesis, and biological activity of 4-[(4-cyano-2-arylbenzyloxy)-(3-methyl-3H-imidazol-4-yl)methyl]benzonitriles as potent and selective farnesyltransferase inhibitors.

Wang L, Wang GT, Wang X, Tong Y, Sullivan G, Park D, Leonard NM, Li Q, Cohen J, Gu WZ, Zhang H, Bauch JL, Jakob CG, Hutchins CW, Stoll VS, Marsh K, Rosenberg SH, Sham HL, Lin NH. Wang L, et al. Among authors: zhang h. J Med Chem. 2004 Jan 29;47(3):612-26. doi: 10.1021/jm030434f. J Med Chem. 2004. PMID: 14736242

9

Synthesis of 1H-pyridin-2-one derivatives as potent and selective farnesyltransferase inhibitors.

Wang L, Lin NH, Li Q, Henry RF, Zhang H, Cohen J, Gu WZ, Marsh KC, Bauch JL, Rosenberg SH, Sham HL. Wang L, et al. Among authors: zhang h. Bioorg Med Chem Lett. 2004 Sep 20;14(18):4603-6. doi: 10.1016/j.bmcl.2004.07.004. Bioorg Med Chem Lett. 2004. PMID: 15324873

10

Synthesis and biological evaluation of 1-benzyl-5-(3-biphenyl-2-yl-propyl)-1H-imidazole as novel farnesyltransferase inhibitor.

Lin NH, Wang L, Wang X, Wang GT, Cohen J, Gu WZ, Zhang H, Rosenberg SH, Sham HL. Lin NH, et al. Among authors: zhang h. Bioorg Med Chem Lett. 2004 Oct 18;14(20):5057-62. doi: 10.1016/j.bmcl.2004.07.083. Bioorg Med Chem Lett. 2004. PMID: 15380198

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