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Page 1
Discovery of N-(2-chloro-6-methyl- phenyl)-2-(6-(4-(2-hydroxyethyl)- piperazin-1-yl)-2-methylpyrimidin-4- ylamino)thiazole-5-carboxamide (BMS-354825), a dual Src/Abl kinase inhibitor with potent antitumor activity in preclinical assays.
Lombardo LJ, Lee FY, Chen P, Norris D, Barrish JC, Behnia K, Castaneda S, Cornelius LA, Das J, Doweyko AM, Fairchild C, Hunt JT, Inigo I, Johnston K, Kamath A, Kan D, Klei H, Marathe P, Pang S, Peterson R, Pitt S, Schieven GL, Schmidt RJ, Tokarski J, Wen ML, Wityak J, Borzilleri RM. Lombardo LJ, et al. Among authors: johnston k. J Med Chem. 2004 Dec 30;47(27):6658-61. doi: 10.1021/jm049486a. J Med Chem. 2004. PMID: 15615512
Synthesis and biological activity of A-nor-paclitaxel analogues.
Chordia MD, Kingston DG, Hamel E, Lin CM, Long BH, Fairchild CA, Johnston KA, Rose WC. Chordia MD, et al. Among authors: johnston ka. Bioorg Med Chem. 1997 May;5(5):941-7. doi: 10.1016/s0968-0896(97)00035-7. Bioorg Med Chem. 1997. PMID: 9208103
Synthesis and biological evaluation of 2-acyl analogues of paclitaxel (Taxol).
Kingston DG, Chaudhary AG, Chordia MD, Gharpure M, Gunatilaka AA, Higgs PI, Rimoldi JM, Samala L, Jagtap PG, Giannakakou P, Jiang YQ, Lin CM, Hamel E, Long BH, Fairchild CR, Johnston KA. Kingston DG, et al. Among authors: johnston ka. J Med Chem. 1998 Sep 10;41(19):3715-26. doi: 10.1021/jm980229d. J Med Chem. 1998. PMID: 9733497
Synthesis and bioactivity of 2,4-diacyl analogues of paclitaxel.
Chordia MD, Yuan H, Jagtap PG, Kadow JF, Long BH, Fairchild CR, Johnston KA, Kingston DG. Chordia MD, et al. Among authors: johnston ka. Bioorg Med Chem. 2001 Jan;9(1):171-8. doi: 10.1016/s0968-0896(00)00233-9. Bioorg Med Chem. 2001. PMID: 11197337
Synthesis of metabolically blocked paclitaxel analogues.
Wittman MD, Altstadt TJ, Fairchild C, Hansel S, Johnston K, Kadow JF, Long BH, Rose WC, Vyas DM, Wu MJ, Zoeckler ME. Wittman MD, et al. Among authors: johnston k. Bioorg Med Chem Lett. 2001 Mar 26;11(6):809-10. doi: 10.1016/s0960-894x(01)00066-x. Bioorg Med Chem Lett. 2001. PMID: 11277525
Preclinical efficacy spectrum and pharmacokinetics of ixabepilone.
Lee FY, Smykla R, Johnston K, Menard K, McGlinchey K, Peterson RW, Wiebesiek A, Vite G, Fairchild CR, Kramer R. Lee FY, et al. Among authors: johnston k. Cancer Chemother Pharmacol. 2009 Jan;63(2):201-12. doi: 10.1007/s00280-008-0727-5. Epub 2008 Mar 19. Cancer Chemother Pharmacol. 2009. PMID: 18350296
1,884 results