Conzelmann E - Search Results

1

Alpha-methylacyl-CoA racemase from Mycobacterium tuberculosis. Mutational and structural characterization of the active site and the fold.

Savolainen K, Bhaumik P, Schmitz W, Kotti TJ, Conzelmann E, Wierenga RK, Hiltunen JK. Savolainen K, et al. Among authors: conzelmann e. J Biol Chem. 2005 Apr 1;280(13):12611-20. doi: 10.1074/jbc.M409704200. Epub 2005 Jan 4. J Biol Chem. 2005. PMID: 15632186 Free article.

2

Crystallization and preliminary X-ray diffraction studies of an alpha-methylacyl-CoA racemase from Mycobacterium tuberculosis.

Bhaumik P, Kursula P, Ratas V, Conzelmann E, Hiltunen JK, Schmitz W, Wierenga RK. Bhaumik P, et al. Among authors: conzelmann e. Acta Crystallogr D Biol Crystallogr. 2003 Feb;59(Pt 2):353-5. doi: 10.1107/s0907444902020735. Epub 2003 Jan 23. Acta Crystallogr D Biol Crystallogr. 2003. PMID: 12554951

3

A mouse model for alpha-methylacyl-CoA racemase deficiency: adjustment of bile acid synthesis and intolerance to dietary methyl-branched lipids.

Savolainen K, Kotti TJ, Schmitz W, Savolainen TI, Sormunen RT, Ilves M, Vainio SJ, Conzelmann E, Hiltunen JK. Savolainen K, et al. Among authors: conzelmann e. Hum Mol Genet. 2004 May 1;13(9):955-65. doi: 10.1093/hmg/ddh107. Epub 2004 Mar 11. Hum Mol Genet. 2004. PMID: 15016763

4

The catalysis of the 1,1-proton transfer by alpha-methyl-acyl-CoA racemase is coupled to a movement of the fatty acyl moiety over a hydrophobic, methionine-rich surface.

Bhaumik P, Schmitz W, Hassinen A, Hiltunen JK, Conzelmann E, Wierenga RK. Bhaumik P, et al. Among authors: conzelmann e. J Mol Biol. 2007 Apr 6;367(4):1145-61. doi: 10.1016/j.jmb.2007.01.062. Epub 2007 Jan 27. J Mol Biol. 2007. PMID: 17320106

5

The enolization chemistry of a thioester-dependent racemase: the 1.4 Å crystal structure of a reaction intermediate complex characterized by detailed QM/MM calculations.

Sharma S, Bhaumik P, Schmitz W, Venkatesan R, Hiltunen JK, Conzelmann E, Juffer AH, Wierenga RK. Sharma S, et al. Among authors: conzelmann e. J Phys Chem B. 2012 Mar 22;116(11):3619-29. doi: 10.1021/jp210185m. Epub 2012 Mar 7. J Phys Chem B. 2012. PMID: 22360758

6

Metabolic adaptation allows Amacr-deficient mice to remain symptom-free despite low levels of mature bile acids.

Selkälä EM, Kuusisto SM, Salonurmi T, Savolainen MJ, Jauhiainen M, Pirilä PL, Kvist AP, Conzelmann E, Schmitz W, Alexson SE, Kotti TJ, Hiltunen JK, Autio KJ. Selkälä EM, et al. Among authors: conzelmann e. Biochim Biophys Acta. 2013 Aug;1831(8):1335-43. doi: 10.1016/j.bbalip.2013.05.002. Epub 2013 May 13. Biochim Biophys Acta. 2013. PMID: 23680781

7

In mouse alpha -methylacyl-CoA racemase, the same gene product is simultaneously located in mitochondria and peroxisomes.

Kotti TJ, Savolainen K, Helander HM, Yagi A, Novikov DK, Kalkkinen N, Conzelmann E, Hiltunen JK, Schmitz W. Kotti TJ, et al. Among authors: conzelmann e. J Biol Chem. 2000 Jul 7;275(27):20887-95. doi: 10.1074/jbc.M002067200. J Biol Chem. 2000. PMID: 10770938 Free article.

8

Molecular cloning of cDNA species for rat and mouse liver alpha-methylacyl-CoA racemases.

Schmitz W, Helander HM, Hiltunen JK, Conzelmann E. Schmitz W, et al. Among authors: conzelmann e. Biochem J. 1997 Sep 15;326 ( Pt 3)(Pt 3):883-9. doi: 10.1042/bj3260883. Biochem J. 1997. PMID: 9307041 Free PMC article.

9

The role of alpha-methylacyl-CoA racemase in bile acid synthesis.

Cuebas DA, Phillips C, Schmitz W, Conzelmann E, Novikov DK. Cuebas DA, et al. Among authors: conzelmann e. Biochem J. 2002 May 1;363(Pt 3):801-7. doi: 10.1042/0264-6021:3630801. Biochem J. 2002. PMID: 11964182 Free PMC article.

10

Mitochondrial 2,4-dienoyl-CoA reductase deficiency in mice results in severe hypoglycemia with stress intolerance and unimpaired ketogenesis.

Miinalainen IJ, Schmitz W, Huotari A, Autio KJ, Soininen R, Ver Loren van Themaat E, Baes M, Herzig KH, Conzelmann E, Hiltunen JK. Miinalainen IJ, et al. Among authors: conzelmann e. PLoS Genet. 2009 Jul;5(7):e1000543. doi: 10.1371/journal.pgen.1000543. Epub 2009 Jul 3. PLoS Genet. 2009. PMID: 19578400 Free PMC article.

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