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A potent small molecule inhibits polyglutamine aggregation in Huntington's disease neurons and suppresses neurodegeneration in vivo.
Zhang X, Smith DL, Meriin AB, Engemann S, Russel DE, Roark M, Washington SL, Maxwell MM, Marsh JL, Thompson LM, Wanker EE, Young AB, Housman DE, Bates GP, Sherman MY, Kazantsev AG. Zhang X, et al. Among authors: housman de. Proc Natl Acad Sci U S A. 2005 Jan 18;102(3):892-7. doi: 10.1073/pnas.0408936102. Epub 2005 Jan 10. Proc Natl Acad Sci U S A. 2005. PMID: 15642944 Free PMC article.
Structure and expression of the Huntington's disease gene: evidence against simple inactivation due to an expanded CAG repeat.
Ambrose CM, Duyao MP, Barnes G, Bates GP, Lin CS, Srinidhi J, Baxendale S, Hummerich H, Lehrach H, Altherr M, Wasmuth J, Buckler A, Church D, Housman D, Berks M, Micklem G, Durbin R, Dodge A, Read A, Gusella J, MacDonald ME. Ambrose CM, et al. Somat Cell Mol Genet. 1994 Jan;20(1):27-38. doi: 10.1007/BF02257483. Somat Cell Mol Genet. 1994. PMID: 8197474
A cell-based assay for aggregation inhibitors as therapeutics of polyglutamine-repeat disease and validation in Drosophila.
Apostol BL, Kazantsev A, Raffioni S, Illes K, Pallos J, Bodai L, Slepko N, Bear JE, Gertler FB, Hersch S, Housman DE, Marsh JL, Thompson LM. Apostol BL, et al. Among authors: housman de. Proc Natl Acad Sci U S A. 2003 May 13;100(10):5950-5. doi: 10.1073/pnas.2628045100. Epub 2003 May 1. Proc Natl Acad Sci U S A. 2003. PMID: 12730384 Free PMC article.
259 results