Kazantsev AG - Search Results

1

A potent small molecule inhibits polyglutamine aggregation in Huntington's disease neurons and suppresses neurodegeneration in vivo.

Zhang X, Smith DL, Meriin AB, Engemann S, Russel DE, Roark M, Washington SL, Maxwell MM, Marsh JL, Thompson LM, Wanker EE, Young AB, Housman DE, Bates GP, Sherman MY, Kazantsev AG. Zhang X, et al. Among authors: kazantsev ag. Proc Natl Acad Sci U S A. 2005 Jan 18;102(3):892-7. doi: 10.1073/pnas.0408936102. Epub 2005 Jan 10. Proc Natl Acad Sci U S A. 2005. PMID: 15642944 Free PMC article.

2

Pharmacological promotion of inclusion formation: a therapeutic approach for Huntington's and Parkinson's diseases.

Bodner RA, Outeiro TF, Altmann S, Maxwell MM, Cho SH, Hyman BT, McLean PJ, Young AB, Housman DE, Kazantsev AG. Bodner RA, et al. Among authors: kazantsev ag. Proc Natl Acad Sci U S A. 2006 Mar 14;103(11):4246-51. doi: 10.1073/pnas.0511256103. Epub 2006 Mar 6. Proc Natl Acad Sci U S A. 2006. PMID: 16537516 Free PMC article.

3

A small-molecule therapeutic lead for Huntington's disease: preclinical pharmacology and efficacy of C2-8 in the R6/2 transgenic mouse.

Chopra V, Fox JH, Lieberman G, Dorsey K, Matson W, Waldmeier P, Housman DE, Kazantsev A, Young AB, Hersch S. Chopra V, et al. Proc Natl Acad Sci U S A. 2007 Oct 16;104(42):16685-9. doi: 10.1073/pnas.0707842104. Epub 2007 Oct 9. Proc Natl Acad Sci U S A. 2007. PMID: 17925440 Free PMC article.

4

RNA interference-mediated silencing of mutant superoxide dismutase rescues cyclosporin A-induced death in cultured neuroblastoma cells.

Maxwell MM, Pasinelli P, Kazantsev AG, Brown RH Jr. Maxwell MM, et al. Among authors: kazantsev ag. Proc Natl Acad Sci U S A. 2004 Mar 2;101(9):3178-83. doi: 10.1073/pnas.0308726100. Epub 2004 Feb 23. Proc Natl Acad Sci U S A. 2004. PMID: 14981234 Free PMC article.

5

Discovery of a novel small-molecule targeting selective clearance of mutant huntingtin fragments.

Coufal M, Maxwell MM, Russel DE, Amore AM, Altmann SM, Hollingsworth ZR, Young AB, Housman DE, Kazantsev AG. Coufal M, et al. Among authors: kazantsev ag. J Biomol Screen. 2007 Apr;12(3):351-60. doi: 10.1177/1087057107299428. Epub 2007 Mar 22. J Biomol Screen. 2007. PMID: 17379859

6

SIRT2 inhibition achieves neuroprotection by decreasing sterol biosynthesis.

Luthi-Carter R, Taylor DM, Pallos J, Lambert E, Amore A, Parker A, Moffitt H, Smith DL, Runne H, Gokce O, Kuhn A, Xiang Z, Maxwell MM, Reeves SA, Bates GP, Neri C, Thompson LM, Marsh JL, Kazantsev AG. Luthi-Carter R, et al. Among authors: kazantsev ag. Proc Natl Acad Sci U S A. 2010 Apr 27;107(17):7927-32. doi: 10.1073/pnas.1002924107. Epub 2010 Apr 8. Proc Natl Acad Sci U S A. 2010. PMID: 20378838 Free PMC article.

7

SIRT2- and NRF2-Targeting Thiazole-Containing Compound with Therapeutic Activity in Huntington's Disease Models.

Quinti L, Casale M, Moniot S, Pais TF, Van Kanegan MJ, Kaltenbach LS, Pallos J, Lim RG, Naidu SD, Runne H, Meisel L, Rauf NA, Leyfer D, Maxwell MM, Saiah E, Landers JE, Luthi-Carter R, Abagyan R, Dinkova-Kostova AT, Steegborn C, Marsh JL, Lo DC, Thompson LM, Kazantsev AG. Quinti L, et al. Among authors: kazantsev ag. Cell Chem Biol. 2016 Jul 21;23(7):849-861. doi: 10.1016/j.chembiol.2016.05.015. Epub 2016 Jul 14. Cell Chem Biol. 2016. PMID: 27427231 Free article.

8

Insoluble detergent-resistant aggregates form between pathological and nonpathological lengths of polyglutamine in mammalian cells.

Kazantsev A, Preisinger E, Dranovsky A, Goldgaber D, Housman D. Kazantsev A, et al. Proc Natl Acad Sci U S A. 1999 Sep 28;96(20):11404-9. doi: 10.1073/pnas.96.20.11404. Proc Natl Acad Sci U S A. 1999. PMID: 10500189 Free PMC article.

9

The Huntington's disease protein interacts with p53 and CREB-binding protein and represses transcription.

Steffan JS, Kazantsev A, Spasic-Boskovic O, Greenwald M, Zhu YZ, Gohler H, Wanker EE, Bates GP, Housman DE, Thompson LM. Steffan JS, et al. Proc Natl Acad Sci U S A. 2000 Jun 6;97(12):6763-8. doi: 10.1073/pnas.100110097. Proc Natl Acad Sci U S A. 2000. PMID: 10823891 Free PMC article.

10

Human single-chain Fv intrabodies counteract in situ huntingtin aggregation in cellular models of Huntington's disease.

Lecerf JM, Shirley TL, Zhu Q, Kazantsev A, Amersdorfer P, Housman DE, Messer A, Huston JS. Lecerf JM, et al. Proc Natl Acad Sci U S A. 2001 Apr 10;98(8):4764-9. doi: 10.1073/pnas.071058398. Proc Natl Acad Sci U S A. 2001. PMID: 11296304 Free PMC article.

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