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A randomized, double-blind, 8-week crossover study of once-daily controlled-release tramadol versus immediate-release tramadol taken as needed for chronic noncancer pain.
Beaulieu AD, Peloso P, Bensen W, Clark AJ, Watson CP, Gardner-Nix J, Thomson G, Piraino PS, Eisenhoffer J, Harsanyi Z, Darke AC. Beaulieu AD, et al. Among authors: harsanyi z. Clin Ther. 2007 Jan;29(1):49-60. doi: 10.1016/j.clinthera.2007.01.001. Clin Ther. 2007. PMID: 17379046 Clinical Trial.
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