The 99 and 170 loop-modified factor VIIa mutants show enhanced catalytic activity without tissue factor.
Soejima K, Yuguchi M, Mizuguchi J, Tomokiyo K, Nakashima T, Nakagaki T, Iwanaga S.
Soejima K, et al. Among authors: nakagaki t.
J Biol Chem. 2002 Dec 13;277(50):49027-35. doi: 10.1074/jbc.M203091200. Epub 2002 Oct 2.
J Biol Chem. 2002.
PMID: 12364340
Free article.
In our previous paper (Soejima, K., Mizuguchi, J., Yuguchi, M., Nakagaki, T., Higashi, S., and Iwanaga, S. (2001) J. Biol. Chem. 276, 17229-17235), the replacement of the 170 loop of VIIa with that of trypsin induced a 10-fold enhancement of the k(cat) value for S-2 …
In our previous paper (Soejima, K., Mizuguchi, J., Yuguchi, M., Nakagaki, T., Higashi, S., and Iwanaga, S. (2001) J. Biol. Che …