Wolfenden R - Search Results

1

The effective molarity of the substrate phosphoryl group in the transition state for yeast OMP decarboxylase.

Sievers A, Wolfenden R. Sievers A, et al. Among authors: wolfenden r. Bioorg Chem. 2005 Feb;33(1):45-52. doi: 10.1016/j.bioorg.2004.08.005. Bioorg Chem. 2005. PMID: 15668182

2

Orotidine-5'-monophosphate decarboxylase catalysis: kinetic isotope effects and the state of hybridization of a bound transition-state analogue.

Acheson SA, Bell JB, Jones ME, Wolfenden R. Acheson SA, et al. Among authors: wolfenden r. Biochemistry. 1990 Apr 3;29(13):3198-202. doi: 10.1021/bi00465a007. Biochemistry. 1990. PMID: 2334689

3

Major enhancement of the affinity of an enzyme for a transition-state analog by a single hydroxyl group.

Kati WM, Wolfenden R. Kati WM, et al. Among authors: wolfenden r. Science. 1989 Mar 24;243(4898):1591-3. doi: 10.1126/science.2928795. Science. 1989. PMID: 2928795

4

Major contribution of a carboxymethyl group to transition-state stabilization by cytidine deaminase: mutation and rescue.

Carlow DC, Smith AA, Yang CC, Short SA, Wolfenden R. Carlow DC, et al. Among authors: wolfenden r. Biochemistry. 1995 Apr 4;34(13):4220-4. doi: 10.1021/bi00013a010. Biochemistry. 1995. PMID: 7703234

5

A proficient enzyme.

Radzicka A, Wolfenden R. Radzicka A, et al. Among authors: wolfenden r. Science. 1995 Jan 6;267(5194):90-3. doi: 10.1126/science.7809611. Science. 1995. PMID: 7809611

6

Substrate connectivity effects in the transition state for cytidine deaminase.

Carlow D, Wolfenden R. Carlow D, et al. Among authors: wolfenden r. Biochemistry. 1998 Aug 25;37(34):11873-8. doi: 10.1021/bi980959n. Biochemistry. 1998. PMID: 9718310

7

Conformational aspects of inhibitor design: enzyme-substrate interactions in the transition state.

Wolfenden R. Wolfenden R. Bioorg Med Chem. 1999 May;7(5):647-52. doi: 10.1016/s0968-0896(98)00247-8. Bioorg Med Chem. 1999. PMID: 10400319 Review.

8

Activity of yeast orotidine-5'-phosphate decarboxylase in the absence of metals.

Miller BG, Smiley JA, Short SA, Wolfenden R. Miller BG, et al. Among authors: wolfenden r. J Biol Chem. 1999 Aug 20;274(34):23841-3. doi: 10.1074/jbc.274.34.23841. J Biol Chem. 1999. PMID: 10446147 Free article.

9

Anatomy of a proficient enzyme: the structure of orotidine 5'-monophosphate decarboxylase in the presence and absence of a potential transition state analog.

Miller BG, Hassell AM, Wolfenden R, Milburn MV, Short SA. Miller BG, et al. Among authors: wolfenden r. Proc Natl Acad Sci U S A. 2000 Feb 29;97(5):2011-6. doi: 10.1073/pnas.030409797. Proc Natl Acad Sci U S A. 2000. PMID: 10681417 Free PMC article.

10

Contribution of enzyme-phosphoribosyl contacts to catalysis by orotidine 5'-phosphate decarboxylase.

Miller BG, Snider MJ, Short SA, Wolfenden R. Miller BG, et al. Among authors: wolfenden r. Biochemistry. 2000 Jul 18;39(28):8113-8. doi: 10.1021/bi000818x. Biochemistry. 2000. PMID: 10889016

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