Adams JM - Search Results

1

Differential targeting of prosurvival Bcl-2 proteins by their BH3-only ligands allows complementary apoptotic function.

Chen L, Willis SN, Wei A, Smith BJ, Fletcher JI, Hinds MG, Colman PM, Day CL, Adams JM, Huang DC. Chen L, et al. Among authors: adams jm. Mol Cell. 2005 Feb 4;17(3):393-403. doi: 10.1016/j.molcel.2004.12.030. Mol Cell. 2005. PMID: 15694340 Free article.

2

Proapoptotic BH3-only proteins trigger membrane integration of prosurvival Bcl-w and neutralize its activity.

Wilson-Annan J, O'Reilly LA, Crawford SA, Hausmann G, Beaumont JG, Parma LP, Chen L, Lackmann M, Lithgow T, Hinds MG, Day CL, Adams JM, Huang DC. Wilson-Annan J, et al. Among authors: adams jm. J Cell Biol. 2003 Sep 1;162(5):877-87. doi: 10.1083/jcb.200302144. J Cell Biol. 2003. PMID: 12952938 Free PMC article.

3

The Bcl-2 family: roles in cell survival and oncogenesis.

Cory S, Huang DC, Adams JM. Cory S, et al. Among authors: adams jm. Oncogene. 2003 Nov 24;22(53):8590-607. doi: 10.1038/sj.onc.1207102. Oncogene. 2003. PMID: 14634621 Review.

4

Proapoptotic Bak is sequestered by Mcl-1 and Bcl-xL, but not Bcl-2, until displaced by BH3-only proteins.

Willis SN, Chen L, Dewson G, Wei A, Naik E, Fletcher JI, Adams JM, Huang DC. Willis SN, et al. Among authors: adams jm. Genes Dev. 2005 Jun 1;19(11):1294-305. doi: 10.1101/gad.1304105. Epub 2005 May 18. Genes Dev. 2005. PMID: 15901672 Free PMC article.

5

Life in the balance: how BH3-only proteins induce apoptosis.

Willis SN, Adams JM. Willis SN, et al. Among authors: adams jm. Curr Opin Cell Biol. 2005 Dec;17(6):617-25. doi: 10.1016/j.ceb.2005.10.001. Epub 2005 Oct 21. Curr Opin Cell Biol. 2005. PMID: 16243507 Free PMC article. Review.

6

The BH3 mimetic ABT-737 targets selective Bcl-2 proteins and efficiently induces apoptosis via Bak/Bax if Mcl-1 is neutralized.

van Delft MF, Wei AH, Mason KD, Vandenberg CJ, Chen L, Czabotar PE, Willis SN, Scott CL, Day CL, Cory S, Adams JM, Roberts AW, Huang DC. van Delft MF, et al. Among authors: adams jm. Cancer Cell. 2006 Nov;10(5):389-99. doi: 10.1016/j.ccr.2006.08.027. Cancer Cell. 2006. PMID: 17097561 Free PMC article.

7

Apoptosis initiated when BH3 ligands engage multiple Bcl-2 homologs, not Bax or Bak.

Willis SN, Fletcher JI, Kaufmann T, van Delft MF, Chen L, Czabotar PE, Ierino H, Lee EF, Fairlie WD, Bouillet P, Strasser A, Kluck RM, Adams JM, Huang DC. Willis SN, et al. Among authors: adams jm. Science. 2007 Feb 9;315(5813):856-9. doi: 10.1126/science.1133289. Science. 2007. PMID: 17289999

8

Mitochondrial permeabilization relies on BH3 ligands engaging multiple prosurvival Bcl-2 relatives, not Bak.

Uren RT, Dewson G, Chen L, Coyne SC, Huang DC, Adams JM, Kluck RM. Uren RT, et al. Among authors: adams jm. J Cell Biol. 2007 Apr 23;177(2):277-87. doi: 10.1083/jcb.200606065. J Cell Biol. 2007. PMID: 17452531 Free PMC article.

9

To trigger apoptosis, Bak exposes its BH3 domain and homodimerizes via BH3:groove interactions.

Dewson G, Kratina T, Sim HW, Puthalakath H, Adams JM, Colman PM, Kluck RM. Dewson G, et al. Among authors: adams jm. Mol Cell. 2008 May 9;30(3):369-80. doi: 10.1016/j.molcel.2008.04.005. Mol Cell. 2008. PMID: 18471982 Free article.

10

Apoptosis is triggered when prosurvival Bcl-2 proteins cannot restrain Bax.

Fletcher JI, Meusburger S, Hawkins CJ, Riglar DT, Lee EF, Fairlie WD, Huang DC, Adams JM. Fletcher JI, et al. Among authors: adams jm. Proc Natl Acad Sci U S A. 2008 Nov 25;105(47):18081-7. doi: 10.1073/pnas.0808691105. Epub 2008 Nov 3. Proc Natl Acad Sci U S A. 2008. PMID: 18981409 Free PMC article.

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