Virus-directed enzyme prodrug therapy: intratumoral administration of a replication-deficient adenovirus encoding nitroreductase to patients with resectable liver cancer.
Palmer DH, Mautner V, Mirza D, Oliff S, Gerritsen W, van der Sijp JR, Hubscher S, Reynolds G, Bonney S, Rajaratnam R, Hull D, Horne M, Ellis J, Mountain A, Hill S, Harris PA, Searle PF, Young LS, James ND, Kerr DJ.
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J Clin Oncol. 2004 May 1;22(9):1546-52. doi: 10.1200/JCO.2004.10.005. Epub 2004 Mar 29.
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PMID: 15051757
Clinical Trial.