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Identification of pathway-selective estrogen receptor ligands that inhibit NF-kappaB transcriptional activity.
Chadwick CC, Chippari S, Matelan E, Borges-Marcucci L, Eckert AM, Keith JC Jr, Albert LM, Leathurby Y, Harris HA, Bhat RA, Ashwell M, Trybulski E, Winneker RC, Adelman SJ, Steffan RJ, Harnish DC. Chadwick CC, et al. Among authors: albert lm. Proc Natl Acad Sci U S A. 2005 Feb 15;102(7):2543-8. doi: 10.1073/pnas.0405841102. Epub 2005 Feb 7. Proc Natl Acad Sci U S A. 2005. PMID: 15699342 Free PMC article.
Evaluation of an estrogen receptor-beta agonist in animal models of human disease.
Harris HA, Albert LM, Leathurby Y, Malamas MS, Mewshaw RE, Miller CP, Kharode YP, Marzolf J, Komm BS, Winneker RC, Frail DE, Henderson RA, Zhu Y, Keith JC Jr. Harris HA, et al. Among authors: albert lm. Endocrinology. 2003 Oct;144(10):4241-9. doi: 10.1210/en.2003-0550. Endocrinology. 2003. PMID: 14500559
Indole cytosolic phospholipase A2 alpha inhibitors: discovery and in vitro and in vivo characterization of 4-{3-[5-chloro-2-(2-{[(3,4-dichlorobenzyl)sulfonyl]amino}ethyl)-1-(diphenylmethyl)-1H-indol-3-yl]propyl}benzoic acid, efipladib.
McKew JC, Lee KL, Shen MW, Thakker P, Foley MA, Behnke ML, Hu B, Sum FW, Tam S, Hu Y, Chen L, Kirincich SJ, Michalak R, Thomason J, Ipek M, Wu K, Wooder L, Ramarao MK, Murphy EA, Goodwin DG, Albert L, Xu X, Donahue F, Ku MS, Keith J, Nickerson-Nutter CL, Abraham WM, Williams C, Hegen M, Clark JD. McKew JC, et al. J Med Chem. 2008 Jun 26;51(12):3388-413. doi: 10.1021/jm701467e. Epub 2008 May 23. J Med Chem. 2008. PMID: 18498150
17 results