Jin X - Search Results

1

Novel diamino derivatives of [1,2,4]triazolo[1,5-a][1,3,5]triazine as potent and selective adenosine A2a receptor antagonists.

Vu CB, Pan D, Peng B, Kumaravel G, Smits G, Jin X, Phadke D, Engber T, Huang C, Reilly J, Tam S, Grant D, Hetu G, Petter RC. Vu CB, et al. Among authors: jin x. J Med Chem. 2005 Mar 24;48(6):2009-18. doi: 10.1021/jm0498396. J Med Chem. 2005. PMID: 15771443

2

Norbornyllactone-substituted xanthines as adenosine A(1) receptor antagonists.

Kiesman WF, Zhao J, Conlon PR, Petter RC, Jin X, Smits G, Lutterodt F, Sullivan GW, Linden J. Kiesman WF, et al. Among authors: jin x. Bioorg Med Chem. 2006 Jun 1;14(11):3654-61. doi: 10.1016/j.bmc.2006.01.021. Epub 2006 Feb 2. Bioorg Med Chem. 2006. PMID: 16458010

3

Potent and orally bioavailable 8-bicyclo[2.2.2]octylxanthines as adenosine A1 receptor antagonists.

Kiesman WF, Zhao J, Conlon PR, Dowling JE, Petter RC, Lutterodt F, Jin X, Smits G, Fure M, Jayaraj A, Kim J, Sullivan G, Linden J. Kiesman WF, et al. Among authors: jin x. J Med Chem. 2006 Nov 30;49(24):7119-31. doi: 10.1021/jm0605381. J Med Chem. 2006. PMID: 17125264

4

Tricyclic imidazoline derivatives as potent and selective adenosine A1 receptor antagonists.

Vu CB, Kiesman WF, Conlon PR, Lin KC, Tam M, Petter RC, Smits G, Lutterodt F, Jin X, Chen L, Zhang J. Vu CB, et al. Among authors: jin x. J Med Chem. 2006 Nov 30;49(24):7132-9. doi: 10.1021/jm060539t. J Med Chem. 2006. PMID: 17125265

5

Piperazine derivatives of [1,2,4]triazolo[1,5-a][1,3,5]triazine as potent and selective adenosine A2a receptor antagonists.

Vu CB, Peng B, Kumaravel G, Smits G, Jin X, Phadke D, Engber T, Huang C, Reilly J, Tam S, Grant D, Hetu G, Chen L, Zhang J, Petter RC. Vu CB, et al. Among authors: jin x. J Med Chem. 2004 Aug 12;47(17):4291-9. doi: 10.1021/jm0498405. J Med Chem. 2004. PMID: 15294001

6

Studies on adenosine A2a receptor antagonists: comparison of three core heterocycles.

Vu CB, Pan D, Peng B, Sha L, Kumaravel G, Jin X, Phadke D, Engber T, Huang C, Reilly J, Tam S, Petter RC. Vu CB, et al. Among authors: jin x. Bioorg Med Chem Lett. 2004 Oct 4;14(19):4831-4. doi: 10.1016/j.bmcl.2004.07.047. Bioorg Med Chem Lett. 2004. PMID: 15341933

7

Triamino derivatives of triazolotriazine and triazolopyrimidine as adenosine A2a receptor antagonists.

Vu CB, Shields P, Peng B, Kumaravel G, Jin X, Phadke D, Wang J, Engber T, Ayyub E, Petter RC. Vu CB, et al. Among authors: jin x. Bioorg Med Chem Lett. 2004 Oct 4;14(19):4835-8. doi: 10.1016/j.bmcl.2004.07.048. Bioorg Med Chem Lett. 2004. PMID: 15341934

8

Synthesis of [1,2,4]triazolo[1,5-a]pyrazines as adenosine A2A receptor antagonists.

Dowling JE, Vessels JT, Haque S, Chang HX, van Vloten K, Kumaravel G, Engber T, Jin X, Phadke D, Wang J, Ayyub E, Petter RC. Dowling JE, et al. Among authors: jin x. Bioorg Med Chem Lett. 2005 Nov 1;15(21):4809-13. doi: 10.1016/j.bmcl.2005.07.052. Bioorg Med Chem Lett. 2005. PMID: 16153830

9

Comparison of three different A1 adenosine receptor antagonists on infarct size and multiple cycle ischemic preconditioning in anesthetized dogs.

Auchampach JA, Jin X, Moore J, Wan TC, Kreckler LM, Ge ZD, Narayanan J, Whalley E, Kiesman W, Ticho B, Smits G, Gross GJ. Auchampach JA, et al. Among authors: jin x. J Pharmacol Exp Ther. 2004 Mar;308(3):846-56. doi: 10.1124/jpet.103.057943. Epub 2003 Nov 21. J Pharmacol Exp Ther. 2004. PMID: 14634049

10

Synergistic drug combinations tend to improve therapeutically relevant selectivity.

Lehár J, Krueger AS, Avery W, Heilbut AM, Johansen LM, Price ER, Rickles RJ, Short GF 3rd, Staunton JE, Jin X, Lee MS, Zimmermann GR, Borisy AA. Lehár J, et al. Among authors: jin x. Nat Biotechnol. 2009 Jul;27(7):659-66. doi: 10.1038/nbt.1549. Epub 2009 Jul 5. Nat Biotechnol. 2009. PMID: 19581876 Free PMC article.

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