Hutchins C - Search Results

1

Design, synthesis, and activity of achiral analogs of 2-quinolones and indoles as non-thiol farnesyltransferase inhibitors.

Li Q, Woods KW, Wang W, Lin NH, Claiborne A, Gu WZ, Cohen J, Stoll VS, Hutchins C, Frost D, Rosenberg SH, Sham HL. Li Q, et al. Among authors: hutchins c. Bioorg Med Chem Lett. 2005 Apr 15;15(8):2033-9. doi: 10.1016/j.bmcl.2005.02.062. Bioorg Med Chem Lett. 2005. PMID: 15808463

2

Design, synthesis, and biological activity of 4-[(4-cyano-2-arylbenzyloxy)-(3-methyl-3H-imidazol-4-yl)methyl]benzonitriles as potent and selective farnesyltransferase inhibitors.

Wang L, Wang GT, Wang X, Tong Y, Sullivan G, Park D, Leonard NM, Li Q, Cohen J, Gu WZ, Zhang H, Bauch JL, Jakob CG, Hutchins CW, Stoll VS, Marsh K, Rosenberg SH, Sham HL, Lin NH. Wang L, et al. J Med Chem. 2004 Jan 29;47(3):612-26. doi: 10.1021/jm030434f. J Med Chem. 2004. PMID: 14736242

3

Design and synthesis of o-trifluoromethylbiphenyl substituted 2-amino-nicotinonitriles as inhibitors of farnesyltransferase.

Wang GT, Wang X, Wang W, Hasvold LA, Sullivan G, Hutchins CW, O'Conner S, Gentiles R, Sowin T, Cohen J, Gu WZ, Zhang H, Rosenberg SH, Sham HL. Wang GT, et al. Bioorg Med Chem Lett. 2005 Jan 3;15(1):153-8. doi: 10.1016/j.bmcl.2004.10.014. Bioorg Med Chem Lett. 2005. PMID: 15582430

4

Aryl tetrahydropyridine inhibitors of farnesyltransferase: glycine, phenylalanine and histidine derivatives.

Gwaltney SL 2nd, O'Connor SJ, Nelson LT, Sullivan GM, Imade H, Wang W, Hasvold L, Li Q, Cohen J, Gu WZ, Tahir SK, Bauch J, Marsh K, Ng SC, Frost DJ, Zhang H, Muchmore S, Jakob CG, Stoll V, Hutchins C, Rosenberg SH, Sham HL. Gwaltney SL 2nd, et al. Among authors: hutchins c. Bioorg Med Chem Lett. 2003 Apr 7;13(7):1359-62. doi: 10.1016/s0960-894x(03)00095-7. Bioorg Med Chem Lett. 2003. PMID: 12657282

5

Aryl tetrahydropyridine inhibitors of farnesyltransferase: bioavailable analogues with improved cellular potency.

Gwaltney SL 2nd, O'Connor SJ, Nelson LT, Sullivan GM, Imade H, Wang W, Hasvold L, Li Q, Cohen J, Gu WZ, Tahir SK, Bauch J, Marsh K, Ng SC, Frost DJ, Zhang H, Muchmore S, Jakob CG, Stoll V, Hutchins C, Rosenberg SH, Sham HL. Gwaltney SL 2nd, et al. Among authors: hutchins c. Bioorg Med Chem Lett. 2003 Apr 7;13(7):1363-6. doi: 10.1016/s0960-894x(03)00094-5. Bioorg Med Chem Lett. 2003. PMID: 12657283

6

Design, synthesis, and activity of 4-quinolone and pyridone compounds as nonthiol-containing farnesyltransferase inhibitors.

Li Q, Claiborne A, Li T, Hasvold L, Stoll VS, Muchmore S, Jakob CG, Gu W, Cohen J, Hutchins C, Frost D, Rosenberg SH, Sham HL. Li Q, et al. Among authors: hutchins c. Bioorg Med Chem Lett. 2004 Nov 1;14(21):5367-70. doi: 10.1016/j.bmcl.2004.08.012. Bioorg Med Chem Lett. 2004. PMID: 15454228

7

Synthesis and activity of 1-aryl-1'-imidazolyl methyl ethers as non-thiol farnesyltransferase inhibitors.

Li Q, Wang GT, Li T, Gwaltney SL 2nd, Woods KW, Claiborne A, Wang X, Gu W, Cohen J, Stoll VS, Hutchins C, Frost D, Rosenberg SH, Sham HL. Li Q, et al. Among authors: hutchins c. Bioorg Med Chem Lett. 2004 Nov 1;14(21):5371-6. doi: 10.1016/j.bmcl.2004.08.011. Bioorg Med Chem Lett. 2004. PMID: 15454229

8

Benzimidazolones and indoles as non-thiol farnesyltransferase inhibitors based on tipifarnib scaffold: synthesis and activity.

Li Q, Li T, Woods KW, Gu WZ, Cohen J, Stoll VS, Galicia T, Hutchins C, Frost D, Rosenberg SH, Sham HL. Li Q, et al. Among authors: hutchins c. Bioorg Med Chem Lett. 2005 Jun 2;15(11):2918-22. doi: 10.1016/j.bmcl.2005.03.049. Epub 2005 Apr 21. Bioorg Med Chem Lett. 2005. PMID: 15911281

9

Aminopyridine-based c-Jun N-terminal kinase inhibitors with cellular activity and minimal cross-kinase activity.

Szczepankiewicz BG, Kosogof C, Nelson LT, Liu G, Liu B, Zhao H, Serby MD, Xin Z, Liu M, Gum RJ, Haasch DL, Wang S, Clampit JE, Johnson EF, Lubben TH, Stashko MA, Olejniczak ET, Sun C, Dorwin SA, Haskins K, Abad-Zapatero C, Fry EH, Hutchins CW, Sham HL, Rondinone CM, Trevillyan JM. Szczepankiewicz BG, et al. Among authors: hutchins cw. J Med Chem. 2006 Jun 15;49(12):3563-80. doi: 10.1021/jm060199b. J Med Chem. 2006. PMID: 16759099

10

Discovery and pharmacological evaluation of growth hormone secretagogue receptor antagonists.

Xin Z, Serby MD, Zhao H, Kosogof C, Szczepankiewicz BG, Liu M, Liu B, Hutchins CW, Sarris KA, Hoff ED, Falls HD, Lin CW, Ogiela CA, Collins CA, Brune ME, Bush EN, Droz BA, Fey TA, Knourek-Segel VE, Shapiro R, Jacobson PB, Beno DW, Turner TM, Sham HL, Liu G. Xin Z, et al. Among authors: hutchins cw. J Med Chem. 2006 Jul 27;49(15):4459-69. doi: 10.1021/jm060461g. J Med Chem. 2006. PMID: 16854051

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