Smith PJ - Search Results

1

Design, synthesis and anti-plasmodial evaluation in vitro of new 4-aminoquinoline isatin derivatives.

Chiyanzu I, Clarkson C, Smith PJ, Lehman J, Gut J, Rosenthal PJ, Chibale K. Chiyanzu I, et al. Among authors: smith pj. Bioorg Med Chem. 2005 May 2;13(9):3249-61. doi: 10.1016/j.bmc.2005.02.037. Bioorg Med Chem. 2005. PMID: 15809160

2

Synthesis of totarol amino alcohol derivatives and their antiplasmodial activity and cytotoxicity.

Clarkson C, Musonda CC, Chibale K, Campbell WE, Smith P. Clarkson C, et al. Bioorg Med Chem. 2003 Oct 1;11(20):4417-22. doi: 10.1016/s0968-0896(03)00491-7. Bioorg Med Chem. 2003. PMID: 13129578

3

Ferrocene-pyrimidine conjugates: Synthesis, electrochemistry, physicochemical properties and antiplasmodial activities.

Chopra R, de Kock C, Smith P, Chibale K, Singh K. Chopra R, et al. Eur J Med Chem. 2015 Jul 15;100:1-9. doi: 10.1016/j.ejmech.2015.05.043. Epub 2015 May 30. Eur J Med Chem. 2015. PMID: 26057222

4

Primaquine-pyrimidine hybrids: synthesis and dual-stage antiplasmodial activity.

Kaur H, Machado M, de Kock C, Smith P, Chibale K, Prudêncio M, Singh K. Kaur H, et al. Eur J Med Chem. 2015 Aug 28;101:266-73. doi: 10.1016/j.ejmech.2015.06.045. Epub 2015 Jun 29. Eur J Med Chem. 2015. PMID: 26142491

5

In vitro antimalarial activity of a series of cationic 2,2'-bipyridyl- and 1,10-phenanthrolineplatinum(II) benzoylthiourea complexes.

Egan TJ, Koch KR, Swan PL, Clarkson C, Van Schalkwyk DA, Smith PJ. Egan TJ, et al. Among authors: smith pj. J Med Chem. 2004 May 20;47(11):2926-34. doi: 10.1021/jm031132g. J Med Chem. 2004. PMID: 15139771

6

Synthesis, antimalarial and antitubercular activity of acetylenic chalcones.

Hans RH, Guantai EM, Lategan C, Smith PJ, Wan B, Franzblau SG, Gut J, Rosenthal PJ, Chibale K. Hans RH, et al. Among authors: smith pj. Bioorg Med Chem Lett. 2010 Feb 1;20(3):942-4. doi: 10.1016/j.bmcl.2009.12.062. Epub 2009 Dec 23. Bioorg Med Chem Lett. 2010. PMID: 20045640

7

Synthesis and in vitro evaluation of gold(I) thiosemicarbazone complexes for antimalarial activity.

Khanye SD, Smith GS, Lategan C, Smith PJ, Gut J, Rosenthal PJ, Chibale K. Khanye SD, et al. Among authors: smith gs, smith pj. J Inorg Biochem. 2010 Oct;104(10):1079-83. doi: 10.1016/j.jinorgbio.2010.06.005. Epub 2010 Jul 1. J Inorg Biochem. 2010. PMID: 20621360

8

Design, synthesis and in vitro antimalarial evaluation of triazole-linked chalcone and dienone hybrid compounds.

Guantai EM, Ncokazi K, Egan TJ, Gut J, Rosenthal PJ, Smith PJ, Chibale K. Guantai EM, et al. Among authors: smith pj. Bioorg Med Chem. 2010 Dec 1;18(23):8243-56. doi: 10.1016/j.bmc.2010.10.009. Epub 2010 Oct 31. Bioorg Med Chem. 2010. PMID: 21044845

9

Enone- and chalcone-chloroquinoline hybrid analogues: in silico guided design, synthesis, antiplasmodial activity, in vitro metabolism, and mechanistic studies.

Guantai EM, Ncokazi K, Egan TJ, Gut J, Rosenthal PJ, Bhampidipati R, Kopinathan A, Smith PJ, Chibale K. Guantai EM, et al. Among authors: smith pj. J Med Chem. 2011 May 26;54(10):3637-49. doi: 10.1021/jm200149e. Epub 2011 May 5. J Med Chem. 2011. PMID: 21500839 Free PMC article.

10

Quinoline antimalarials containing a dibemethin group are active against chloroquinone-resistant Plasmodium falciparum and inhibit chloroquine transport via the P. falciparum chloroquine-resistance transporter (PfCRT).

Zishiri VK, Joshi MC, Hunter R, Chibale K, Smith PJ, Summers RL, Martin RE, Egan TJ. Zishiri VK, et al. Among authors: smith pj. J Med Chem. 2011 Oct 13;54(19):6956-68. doi: 10.1021/jm2009698. Epub 2011 Sep 13. J Med Chem. 2011. PMID: 21875063

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