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Autoimmunity and inflammation due to a gain-of-function mutation in phospholipase C gamma 2 that specifically increases external Ca2+ entry.
Yu P, Constien R, Dear N, Katan M, Hanke P, Bunney TD, Kunder S, Quintanilla-Martinez L, Huffstadt U, Schröder A, Jones NP, Peters T, Fuchs H, de Angelis MH, Nehls M, Grosse J, Wabnitz P, Meyer TP, Yasuda K, Schiemann M, Schneider-Fresenius C, Jagla W, Russ A, Popp A, Josephs M, Marquardt A, Laufs J, Schmittwolf C, Wagner H, Pfeffer K, Mudde GC. Yu P, et al. Among authors: mudde gc. Immunity. 2005 Apr;22(4):451-65. doi: 10.1016/j.immuni.2005.01.018. Immunity. 2005. PMID: 15845450 Free article.
A HER2-specific Modified Fc Fragment (Fcab) Induces Antitumor Effects Through Degradation of HER2 and Apoptosis.
Leung KM, Batey S, Rowlands R, Isaac SJ, Jones P, Drewett V, Carvalho J, Gaspar M, Weller S, Medcalf M, Wydro MM, Pegram R, Mudde GC, Bauer A, Moulder K, Woisetschläger M, Tuna M, Haurum JS, Sun H. Leung KM, et al. Among authors: mudde gc. Mol Ther. 2015 Nov;23(11):1722-1733. doi: 10.1038/mt.2015.127. Epub 2015 Aug 3. Mol Ther. 2015. PMID: 26234505 Free PMC article.
Selective Targeting of a Disease-Related Conformational Isoform of Macrophage Migration Inhibitory Factor Ameliorates Inflammatory Conditions.
Thiele M, Kerschbaumer RJ, Tam FW, Völkel D, Douillard P, Schinagl A, Kühnel H, Smith J, McDaid JP, Bhangal G, Yu MC, Pusey CD, Cook HT, Kovarik J, Magelky E, Bhan A, Rieger M, Mudde GC, Ehrlich H, Jilma B, Tilg H, Moschen A, Terhorst C, Scheiflinger F. Thiele M, et al. Among authors: mudde gc. J Immunol. 2015 Sep 1;195(5):2343-52. doi: 10.4049/jimmunol.1500572. Epub 2015 Jul 24. J Immunol. 2015. PMID: 26209628 Free PMC article.
Introducing antigen-binding sites in structural loops of immunoglobulin constant domains: Fc fragments with engineered HER2/neu-binding sites and antibody properties.
Wozniak-Knopp G, Bartl S, Bauer A, Mostageer M, Woisetschläger M, Antes B, Ettl K, Kainer M, Weberhofer G, Wiederkum S, Himmler G, Mudde GC, Rüker F. Wozniak-Knopp G, et al. Among authors: mudde gc. Protein Eng Des Sel. 2010 Apr;23(4):289-97. doi: 10.1093/protein/gzq005. Epub 2010 Feb 11. Protein Eng Des Sel. 2010. PMID: 20150180
68 results