Chen J - Search Results

1

Enantiomerically pure hexahydropyrazinoquinolines as potent and selective dopamine 3 subtype receptor ligands.

Ding K, Chen J, Ji M, Wu X, Varady J, Yang CY, Lu Y, Deschamps JR, Levant B, Wang S. Ding K, et al. Among authors: chen j. J Med Chem. 2005 May 5;48(9):3171-81. doi: 10.1021/jm049031l. J Med Chem. 2005. PMID: 15857123

2

Design, synthesis, and evaluation of hexahydrobenz[f]isoquinolines as a novel class of dopamine 3 receptor ligands.

Wu X, Chen J, Ji M, Varady J, Levant B, Wang S. Wu X, et al. Among authors: chen j. Bioorg Med Chem Lett. 2004 Dec 6;14(23):5813-6. doi: 10.1016/j.bmcl.2004.09.047. Bioorg Med Chem Lett. 2004. PMID: 15501046

3

Preclinical studies of a nonpeptidic small-molecule inhibitor of Bcl-2 and Bcl-X(L) [(-)-gossypol] against diffuse large cell lymphoma.

Mohammad RM, Wang S, Aboukameel A, Chen B, Wu X, Chen J, Al-Katib A. Mohammad RM, et al. Among authors: chen j, chen b. Mol Cancer Ther. 2005 Jan;4(1):13-21. Mol Cancer Ther. 2005. PMID: 15657349

4

Structure-based design, synthesis and biochemical testing of novel and potent Smac peptido-mimetics.

Sun H, Nikolovska-Coleska Z, Chen J, Yang CY, Tomita Y, Pan H, Yoshioka Y, Krajewski K, Roller PP, Wang S. Sun H, et al. Among authors: chen j. Bioorg Med Chem Lett. 2005 Feb 1;15(3):793-7. doi: 10.1016/j.bmcl.2004.11.008. Bioorg Med Chem Lett. 2005. PMID: 15664859

5

(-)-Gossypol enhances response to radiation therapy and results in tumor regression of human prostate cancer.

Xu L, Yang D, Wang S, Tang W, Liu M, Davis M, Chen J, Rae JM, Lawrence T, Lippman ME. Xu L, et al. Among authors: chen j. Mol Cancer Ther. 2005 Feb;4(2):197-205. Mol Cancer Ther. 2005. PMID: 15713891

6

Design, synthesis and structure-activity relationship studies of hexahydropyrazinoquinolines as a novel class of potent and selective dopamine receptor 3 (D3) ligands.

Ji M, Chen J, Ding K, Wu X, Varady J, Levant B, Wang S. Ji M, et al. Among authors: chen j. Bioorg Med Chem Lett. 2005 Mar 15;15(6):1701-5. doi: 10.1016/j.bmcl.2005.01.037. Bioorg Med Chem Lett. 2005. PMID: 15745825

7

Reversal of cisplatin resistance with a BH3 mimetic, (-)-gossypol, in head and neck cancer cells: role of wild-type p53 and Bcl-xL.

Bauer JA, Trask DK, Kumar B, Los G, Castro J, Lee JS, Chen J, Wang S, Bradford CR, Carey TE. Bauer JA, et al. Among authors: chen j. Mol Cancer Ther. 2005 Jul;4(7):1096-104. doi: 10.1158/1535-7163.MCT-05-0081. Mol Cancer Ther. 2005. PMID: 16020667

8

A small molecule compound inhibits AKT pathway in ovarian cancer cell lines.

Tang HJ, Jin X, Wang S, Yang D, Cao Y, Chen J, Gossett DR, Lin J. Tang HJ, et al. Among authors: chen j. Gynecol Oncol. 2006 Feb;100(2):308-17. doi: 10.1016/j.ygyno.2005.08.044. Epub 2005 Oct 4. Gynecol Oncol. 2006. PMID: 16209885

9

Nonpeptidic small-molecule inhibitor of Bcl-2 and Bcl-XL, (-)-Gossypol, enhances biological effect of genistein against BxPC-3 human pancreatic cancer cell line.

Mohammad RM, Wang S, Banerjee S, Wu X, Chen J, Sarkar FH. Mohammad RM, et al. Among authors: chen j. Pancreas. 2005 Nov;31(4):317-24. doi: 10.1097/01.mpa.0000179731.46210.01. Pancreas. 2005. PMID: 16258364

10

Design of novel hexahydropyrazinoquinolines as potent and selective dopamine D3 receptor ligands with improved solubility.

Chen J, Ding K, Levant B, Wang S. Chen J, et al. Bioorg Med Chem Lett. 2006 Jan 15;16(2):443-6. doi: 10.1016/j.bmcl.2005.09.053. Epub 2005 Nov 14. Bioorg Med Chem Lett. 2006. PMID: 16290142

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