Deschamps JR - Search Results

1

Enantiomerically pure hexahydropyrazinoquinolines as potent and selective dopamine 3 subtype receptor ligands.

Ding K, Chen J, Ji M, Wu X, Varady J, Yang CY, Lu Y, Deschamps JR, Levant B, Wang S. Ding K, et al. Among authors: deschamps jr. J Med Chem. 2005 May 5;48(9):3171-81. doi: 10.1021/jm049031l. J Med Chem. 2005. PMID: 15857123

2

Nonpeptidic and potent small-molecule inhibitors of cIAP-1/2 and XIAP proteins.

Sun H, Lu J, Liu L, Yi H, Qiu S, Yang CY, Deschamps JR, Wang S. Sun H, et al. Among authors: deschamps jr. J Med Chem. 2010 Sep 9;53(17):6361-7. doi: 10.1021/jm100487z. J Med Chem. 2010. PMID: 20684551 Free PMC article.

3

CJ-1639: A Potent and Highly Selective Dopamine D3 Receptor Full Agonist.

Chen J, Collins GT, Levant B, Woods J, Deschamps JR, Wang S. Chen J, et al. Among authors: deschamps jr. ACS Med Chem Lett. 2011 Aug 11;2(8):620-625. doi: 10.1021/ml200100t. ACS Med Chem Lett. 2011. PMID: 22125662 Free PMC article.

4

Structure-based design of potent non-peptide MDM2 inhibitors.

Ding K, Lu Y, Nikolovska-Coleska Z, Qiu S, Ding Y, Gao W, Stuckey J, Krajewski K, Roller PP, Tomita Y, Parrish DA, Deschamps JR, Wang S. Ding K, et al. Among authors: deschamps jr. J Am Chem Soc. 2005 Jul 27;127(29):10130-1. doi: 10.1021/ja051147z. J Am Chem Soc. 2005. PMID: 16028899

5

Design of chemically stable, potent, and efficacious MDM2 inhibitors that exploit the retro-mannich ring-opening-cyclization reaction mechanism in spiro-oxindoles.

Aguilar A, Sun W, Liu L, Lu J, McEachern D, Bernard D, Deschamps JR, Wang S. Aguilar A, et al. Among authors: deschamps jr. J Med Chem. 2014 Dec 26;57(24):10486-98. doi: 10.1021/jm501541j. Epub 2014 Dec 12. J Med Chem. 2014. PMID: 25496041 Free PMC article.

6

Structure-activity relationships for a novel series of dopamine D2-like receptor ligands based on N-substituted 3-aryl-8-azabicyclo[3.2.1]octan-3-ol.

Paul NM, Taylor M, Kumar R, Deschamps JR, Luedtke RR, Newman AH. Paul NM, et al. Among authors: deschamps jr. J Med Chem. 2008 Oct 9;51(19):6095-109. doi: 10.1021/jm800532x. Epub 2008 Sep 6. J Med Chem. 2008. PMID: 18774793 Free PMC article.

7

The Significance of Chirality in Drug Design and Synthesis of Bitopic Ligands as D₃ Receptor (D₃R) Selective Agonists.

Battiti FO, Cemaj SL, Guerrero AM, Shaik AB, Lam J, Rais R, Slusher BS, Deschamps JR, Imler GH, Newman AH, Bonifazi A. Battiti FO, et al. Among authors: deschamps jr. J Med Chem. 2019 Jul 11;62(13):6287-6314. doi: 10.1021/acs.jmedchem.9b00702. Epub 2019 Jul 1. J Med Chem. 2019. PMID: 31257877 Free PMC article.

8

N-(4-(4-(2,3-dichloro- or 2-methoxyphenyl)piperazin-1-yl)butyl)heterobiarylcarboxamides with functionalized linking chains as high affinity and enantioselective D3 receptor antagonists.

Newman AH, Grundt P, Cyriac G, Deschamps JR, Taylor M, Kumar R, Ho D, Luedtke RR. Newman AH, et al. Among authors: deschamps jr. J Med Chem. 2009 Apr 23;52(8):2559-70. doi: 10.1021/jm900095y. J Med Chem. 2009. PMID: 19331412 Free PMC article.

9

Using click chemistry toward novel 1,2,3-triazole-linked dopamine D3 receptor ligands.

Keck TM, Banala AK, Slack RD, Burzynski C, Bonifazi A, Okunola-Bakare OM, Moore M, Deschamps JR, Rais R, Slusher BS, Newman AH. Keck TM, et al. Among authors: deschamps jr. Bioorg Med Chem. 2015 Jul 15;23(14):4000-12. doi: 10.1016/j.bmc.2015.01.017. Epub 2015 Jan 17. Bioorg Med Chem. 2015. PMID: 25650314 Free PMC article.

10

Structure-activity relationships comparing N-(6-methylpyridin-yl)-substituted aryl amides to 2-methyl-6-(substituted-arylethynyl)pyridines or 2-methyl-4-(substituted-arylethynyl)thiazoles as novel metabotropic glutamate receptor subtype 5 antagonists.

Kulkarni SS, Zou MF, Cao J, Deschamps JR, Rodriguez AL, Conn PJ, Newman AH. Kulkarni SS, et al. Among authors: deschamps jr. J Med Chem. 2009 Jun 11;52(11):3563-75. doi: 10.1021/jm900172f. J Med Chem. 2009. PMID: 19445453 Free PMC article.

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