Hickson I - Search Results

1

Temozolomide pharmacodynamics in patients with metastatic melanoma: dna damage and activity of repair enzymes O6-alkylguanine alkyltransferase and poly(ADP-ribose) polymerase-1.

Plummer ER, Middleton MR, Jones C, Olsen A, Hickson I, McHugh P, Margison GP, McGown G, Thorncroft M, Watson AJ, Boddy AV, Calvert AH, Harris AL, Newell DR, Curtin NJ. Plummer ER, et al. Among authors: hickson i. Clin Cancer Res. 2005 May 1;11(9):3402-9. doi: 10.1158/1078-0432.CCR-04-2353. Clin Cancer Res. 2005. PMID: 15867241 Free article. Clinical Trial.

2

Protection of mammalian cells against chloroethylating agent toxicity by an O6-benzylguanine-resistant mutant of human O6-alkylguanine-DNA alkyltransferase.

Hickson I, Fairbairn LJ, Chinnasamy N, Dexter TM, Margison GP, Rafferty JA. Hickson I, et al. Gene Ther. 1996 Oct;3(10):868-77. Gene Ther. 1996. PMID: 8908500

3

Chemoprotective gene transfer I: transduction of human haemopoietic progenitors with O6-benzylguanine-resistant O6-alkylguanine-DNA alkyltransferase attenuates the toxic effects of O6-alkylating agents in vitro.

Hickson I, Fairbairn LJ, Chinnasamy N, Lashford LS, Thatcher N, Margison GP, Dexter TM, Rafferty JA. Hickson I, et al. Gene Ther. 1998 Jun;5(6):835-41. doi: 10.1038/sj.gt.3300698. Gene Ther. 1998. PMID: 9747464

4

Chemoprotective gene transfer II: multilineage in vivo protection of haemopoiesis against the effects of an antitumour agent by expression of a mutant human O6-alkylguanine-DNA alkyltransferase.

Chinnasamy N, Rafferty JA, Hickson I, Lashford LS, Longhurst SJ, Thatcher N, Margison GP, Dexter TM, Fairbairn LJ. Chinnasamy N, et al. Among authors: hickson i. Gene Ther. 1998 Jun;5(6):842-7. doi: 10.1038/sj.gt.3300699. Gene Ther. 1998. PMID: 9747465

5

Defective repair of DNA single- and double-strand breaks in the bleomycin- and X-ray-sensitive Chinese hamster ovary cell mutant, BLM-2.

Robson CN, Harris AL, Hickson ID. Robson CN, et al. Among authors: hickson id. Mutat Res. 1989 Mar;217(2):93-100. doi: 10.1016/0921-8777(89)90060-8. Mutat Res. 1989. PMID: 2465493

6

O6-benzylguanine potentiates the in vivo toxicity and clastogenicity of temozolomide and BCNU in mouse bone marrow.

Chinnasamy N, Rafferty JA, Hickson I, Ashby J, Tinwell H, Margison GP, Dexter TM, Fairbairn LJ. Chinnasamy N, et al. Among authors: hickson i. Blood. 1997 Mar 1;89(5):1566-73. Blood. 1997. PMID: 9057638 Free article.

7

Isolation of two Chinese hamster ovary cell mutants hypersensitive to topoisomerase II inhibitors and cross-resistant to peroxides.

Davies SM, Davies SL, Harris AL, Hickson ID. Davies SM, et al. Among authors: hickson id. Cancer Res. 1989 Aug 15;49(16):4526-30. Cancer Res. 1989. PMID: 2545343

8

Possible role of inhibition of glutathione S-transferase in the partial reversal of chlorambucil resistance by indomethacin in a Chinese hamster ovary cell line.

Hall A, Robson CN, Hickson ID, Harris AL, Proctor SJ, Cattan AR. Hall A, et al. Among authors: hickson id. Cancer Res. 1989 Nov 15;49(22):6265-8. Cancer Res. 1989. PMID: 2804972

9

Reduced levels of drug-induced DNA cross-linking in nitrogen mustard-resistant Chinese hamster ovary cells expressing elevated glutathione S-transferase activity.

Robson CN, Lewis AD, Wolf CR, Hayes JD, Hall A, Proctor SJ, Harris AL, Hickson ID. Robson CN, et al. Among authors: hickson id. Cancer Res. 1987 Nov 15;47(22):6022-7. Cancer Res. 1987. PMID: 3664506

10

Chemoprotection of normal tissues by transfer of drug resistance genes.

Rafferty JA, Hickson I, Chinnasamy N, Lashford LS, Margison GP, Dexter TM, Fairbairn LJ. Rafferty JA, et al. Among authors: hickson i. Cancer Metastasis Rev. 1996 Sep;15(3):365-83. doi: 10.1007/BF00046348. Cancer Metastasis Rev. 1996. PMID: 9034597 Review.

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