McDowell RS - Search Results

1

Mambin, a potent glycoprotein IIb-IIIa antagonist and platelet aggregation inhibitor structurally related to the short neurotoxins.

McDowell RS, Dennis MS, Louie A, Shuster M, Mulkerrin MG, Lazarus RA. McDowell RS, et al. Biochemistry. 1992 May 26;31(20):4766-72. doi: 10.1021/bi00135a004. Biochemistry. 1992. PMID: 1591238

2

Structural and functional aspects of RGD-containing protein antagonists of glycoprotein IIb-IIIa.

Lazarus RA, McDowell RS. Lazarus RA, et al. Among authors: mcdowell rs. Curr Opin Biotechnol. 1993 Aug;4(4):438-45. doi: 10.1016/0958-1669(93)90009-l. Curr Opin Biotechnol. 1993. PMID: 7763974 Review.

3

Generation of an LFA-1 antagonist by the transfer of the ICAM-1 immunoregulatory epitope to a small molecule.

Gadek TR, Burdick DJ, McDowell RS, Stanley MS, Marsters JC Jr, Paris KJ, Oare DA, Reynolds ME, Ladner C, Zioncheck KA, Lee WP, Gribling P, Dennis MS, Skelton NJ, Tumas DB, Clark KR, Keating SM, Beresini MH, Tilley JW, Presta LG, Bodary SC. Gadek TR, et al. Among authors: mcdowell rs. Science. 2002 Feb 8;295(5557):1086-9. doi: 10.1126/science.295.5557.1086. Science. 2002. PMID: 11834839

4

Solution conformation of an atrial natriuretic peptide variant selective for the type A receptor.

Fairbrother WJ, McDowell RS, Cunningham BC. Fairbrother WJ, et al. Among authors: mcdowell rs. Biochemistry. 1994 Aug 2;33(30):8897-904. doi: 10.1021/bi00196a006. Biochemistry. 1994. PMID: 8043577

5

Fragment-based discovery of nonpeptidic BACE-1 inhibitors using tethering.

Yang W, Fucini RV, Fahr BT, Randal M, Lind KE, Lam MB, Lu W, Lu Y, Cary DR, Romanowski MJ, Colussi D, Pietrak B, Allison TJ, Munshi SK, Penny DM, Pham P, Sun J, Thomas AE, Wilkinson JM, Jacobs JW, McDowell RS, Ballinger MD. Yang W, et al. Among authors: mcdowell rs. Biochemistry. 2009 Jun 2;48(21):4488-96. doi: 10.1021/bi900017q. Biochemistry. 2009. PMID: 19284778

6

Discovery of a potent small molecule IL-2 inhibitor through fragment assembly.

Braisted AC, Oslob JD, Delano WL, Hyde J, McDowell RS, Waal N, Yu C, Arkin MR, Raimundo BC. Braisted AC, et al. Among authors: mcdowell rs. J Am Chem Soc. 2003 Apr 2;125(13):3714-5. doi: 10.1021/ja034247i. J Am Chem Soc. 2003. PMID: 12656598

7

Benzodiazepine peptidomimetic inhibitors of farnesyltransferase.

Marsters JC Jr, McDowell RS, Reynolds ME, Oare DA, Somers TC, Stanley MS, Rawson TE, Struble ME, Burdick DJ, Chan KS, et al. Marsters JC Jr, et al. Among authors: mcdowell rs. Bioorg Med Chem. 1994 Sep;2(9):949-57. doi: 10.1016/s0968-0896(00)82044-1. Bioorg Med Chem. 1994. PMID: 7712130

8

From peptide to non-peptide. 3. Atropisomeric GPIIbIIIa antagonists containing the 3,4-dihydro-1H-1,4-benzodiazepine-2,5-dione nucleus.

Blackburn BK, Lee A, Baier M, Kohl B, Olivero AG, Matamoros R, Robarge KD, McDowell RS. Blackburn BK, et al. Among authors: mcdowell rs. J Med Chem. 1997 Feb 28;40(5):717-29. doi: 10.1021/jm960652r. J Med Chem. 1997. PMID: 9057858

9

Photolabelling of Salmonella typhimurium LT2 sialidase. Identification of a peptide with a predicted structural similarity to the active sites of influenza-virus sialidases.

Warner TG, Harris R, McDowell R, Vimr ER. Warner TG, et al. Biochem J. 1992 Aug 1;285 ( Pt 3)(Pt 3):957-64. doi: 10.1042/bj2850957. Biochem J. 1992. PMID: 1295492 Free PMC article.

10

IL-8 single-chain homodimers and heterodimers: interactions with chemokine receptors CXCR1, CXCR2, and DARC.

Leong SR, Lowman HB, Liu J, Shire S, Deforge LE, Gillece-Castro BL, McDowell R, Hébert CA. Leong SR, et al. Protein Sci. 1997 Mar;6(3):609-17. doi: 10.1002/pro.5560060310. Protein Sci. 1997. PMID: 9070443 Free PMC article.

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