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Inhibition of NAADP signalling on reperfusion protects the heart by preventing lethal calcium oscillations via two-pore channel 1 and opening of the mitochondrial permeability transition pore.
Davidson SM, Foote K, Kunuthur S, Gosain R, Tan N, Tyser R, Zhao YJ, Graeff R, Ganesan A, Duchen MR, Patel S, Yellon DM. Davidson SM, et al. Among authors: duchen mr. Cardiovasc Res. 2015 Dec 1;108(3):357-66. doi: 10.1093/cvr/cvv226. Epub 2015 Sep 22. Cardiovasc Res. 2015. PMID: 26395965 Free PMC article.
233 results