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A Qualified Success: Discovery of a New Series of ATAD2 Bromodomain Inhibitors with a Novel Binding Mode Using High-Throughput Screening and Hit Qualification.
Bamborough P, Chung CW, Demont EH, Bridges AM, Craggs PD, Dixon DP, Francis P, Furze RC, Grandi P, Jones EJ, Karamshi B, Locke K, Lucas SCC, Michon AM, Mitchell DJ, Pogány P, Prinjha RK, Rau C, Roa AM, Roberts AD, Sheppard RJ, Watson RJ. Bamborough P, et al. Among authors: roa am. J Med Chem. 2019 Aug 22;62(16):7506-7525. doi: 10.1021/acs.jmedchem.9b00673. Epub 2019 Aug 9. J Med Chem. 2019. PMID: 31398032
Phenylalanine-Derived β-Lactam TRPM8 Modulators. Configuration Effect on the Antagonist Activity.
Bonache MÁ, Llabrés PJ, Martín-Escura C, De la Torre-Martínez R, Medina-Peris A, Butrón L, Gómez-Monterrey I, Roa AM, Fernández-Ballester G, Ferrer-Montiel A, Fernández-Carvajal A, González-Muñiz R. Bonache MÁ, et al. Among authors: roa am. Int J Mol Sci. 2021 Feb 27;22(5):2370. doi: 10.3390/ijms22052370. Int J Mol Sci. 2021. PMID: 33673444 Free PMC article.
Highly functionalized β-lactams and 2-ketopiperazines as TRPM8 antagonists with antiallodynic activity.
Bonache MÁ, Martín-Escura C, de la Torre Martínez R, Medina A, González-Rodríguez S, Francesch A, Cuevas C, Roa AM, Fernández-Ballester G, Ferrer-Montiel A, Fernández-Carvajal A, González-Muñiz R. Bonache MÁ, et al. Among authors: roa am. Sci Rep. 2020 Aug 25;10(1):14154. doi: 10.1038/s41598-020-70691-x. Sci Rep. 2020. PMID: 32843690 Free PMC article.
14 results