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Page 1
Analysis of structure-activity relationships for the 'A-region' of N-(4-t-butylbenzyl)-N'-[4-(methylsulfonylamino)benzyl]thiourea analogues as TRPV1 antagonists.
Lee J, Kang SU, Kil MJ, Shin M, Lim JO, Choi HK, Jin MK, Kim SY, Kim SE, Lee YS, Min KH, Kim YH, Ha HJ, Tran R, Welter JD, Wang Y, Szabo T, Pearce LV, Lundberg DJ, Toth A, Pavlyukovets VA, Morgan MA, Blumberg PM. Lee J, et al. Among authors: lim jo. Bioorg Med Chem Lett. 2005 Sep 15;15(18):4136-42. doi: 10.1016/j.bmcl.2005.06.009. Bioorg Med Chem Lett. 2005. PMID: 16005215
N-(3-acyloxy-2-benzylpropyl)-N'-[4-(methylsulfonylamino)benzyl]thiourea analogues: novel potent and high affinity antagonists and partial antagonists of the vanilloid receptor.
Lee J, Lee J, Kang M, Shin M, Kim JM, Kang SU, Lim JO, Choi HK, Suh YG, Park HG, Oh U, Kim HD, Park YH, Ha HJ, Kim YH, Toth A, Wang Y, Tran R, Pearce LV, Lundberg DJ, Blumberg PM. Lee J, et al. Among authors: lim jo. J Med Chem. 2003 Jul 3;46(14):3116-26. doi: 10.1021/jm030089u. J Med Chem. 2003. PMID: 12825950
Analysis of structure-activity relationships for the 'B-region' of N-(3-acyloxy-2-benzylpropyl)-N(')-[4-(methylsulfonylamino)benzyl]thiourea analogues as vanilloid receptor antagonists: discovery of an N-hydroxythiourea analogue with potent analgesic activity.
Lee J, Kang SU, Choi HK, Lee J, Lim JO, Kil MJ, Jin MK, Kim KP, Sung JH, Chung SJ, Ha HJ, Kim YH, Pearce LV, Tran R, Lundberg DJ, Wang Y, Toth A, Blumberg PM. Lee J, et al. Among authors: lim jo. Bioorg Med Chem Lett. 2004 May 3;14(9):2291-7. doi: 10.1016/j.bmcl.2004.02.002. Bioorg Med Chem Lett. 2004. PMID: 15081027
Novel potent antagonists of transient receptor potential channel, vanilloid subfamily member 1: structure-activity relationship of 1,3-diarylalkyl thioureas possessing new vanilloid equivalents.
Suh YG, Lee YS, Min KH, Park OH, Kim JK, Seung HS, Seo SY, Lee BY, Nam YH, Lee KO, Kim HD, Park HG, Lee J, Oh U, Lim JO, Kang SU, Kil MJ, Koo JY, Shin SS, Joo YH, Kim JK, Jeong YS, Kim SY, Park YH. Suh YG, et al. Among authors: lim jo. J Med Chem. 2005 Sep 8;48(18):5823-36. doi: 10.1021/jm0502790. J Med Chem. 2005. PMID: 16134949
Alpha-substituted N-(4-tert-butylbenzyl)-N'-[4-(methylsulfonylamino)benzyl]thiourea analogues as potent and stereospecific TRPV1 antagonists.
Chung JU, Kim SY, Lim JO, Choi HK, Kang SU, Yoon HS, Ryu H, Kang DW, Lee J, Kang B, Choi S, Toth A, Pearce LV, Pavlyukovets VA, Lundberg DJ, Blumberg PM. Chung JU, et al. Among authors: lim jo. Bioorg Med Chem. 2007 Sep 15;15(18):6043-53. doi: 10.1016/j.bmc.2007.06.041. Epub 2007 Jun 26. Bioorg Med Chem. 2007. PMID: 17629487
High-affinity partial agonists of the vanilloid receptor.
Wang Y, Toth A, Tran R, Szabo T, Welter JD, Blumberg PM, Lee J, Kang SU, Lim JO, Lee J. Wang Y, et al. Among authors: lim jo. Mol Pharmacol. 2003 Aug;64(2):325-33. doi: 10.1124/mol.64.2.325. Mol Pharmacol. 2003. PMID: 12869637
127 results