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4-Hydroxybenzyl modification of the highly teratogenic retinoid, 4-[(1E)-2-(5,5,8,8-tetramethyl-5,6,7,8-tetrahydro-2-naphthalenyl)-1-propen-1-yl]benzoic acid (TTNPB), yields a compound that induces apoptosis in breast cancer cells and shows reduced teratogenicity.
Anding AL, Nieves NJ, Abzianidze VV, Collins MD, Curley RW Jr, Clagett-Dame M. Anding AL, et al. Among authors: nieves nj. Chem Res Toxicol. 2011 Nov 21;24(11):1853-61. doi: 10.1021/tx200174n. Epub 2011 Oct 19. Chem Res Toxicol. 2011. PMID: 21939267