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Early, precise, and safe clinical evaluation of the pharmacodynamic effects of novel agents in the intact human tumor microenvironment.
Gundle KR, Rajasekaran K, Houlton J, Deutsch GB, Ow TJ, Maki RG, Pang J, Nathan CO, Clayburgh D, Newman JG, Brinkmann E, Wagner MJ, Pollack SM, Thompson MJ, Li RJ, Mehta V, Schiff BA, Wenig BI, Swiecicki PL, Tang AL, Davis JL, van Zante A, Bertout JA, Jenkins W, Turner A, Grenley M, Burns C, Frazier JP, Merrell A, Sottero KHW, Derry JMJ, Gillespie KC, Mills B, Klinghoffer RA. Gundle KR, et al. Among authors: schiff ba. Front Pharmacol. 2024 Apr 12;15:1367581. doi: 10.3389/fphar.2024.1367581. eCollection 2024. Front Pharmacol. 2024. PMID: 38681192 Free PMC article.
Epidermal growth factor receptor (EGFR) is overexpressed in anaplastic thyroid cancer, and the EGFR inhibitor gefitinib inhibits the growth of anaplastic thyroid cancer.
Schiff BA, McMurphy AB, Jasser SA, Younes MN, Doan D, Yigitbasi OG, Kim S, Zhou G, Mandal M, Bekele BN, Holsinger FC, Sherman SI, Yeung SC, El-Naggar AK, Myers JN. Schiff BA, et al. Clin Cancer Res. 2004 Dec 15;10(24):8594-602. doi: 10.1158/1078-0432.CCR-04-0690. Clin Cancer Res. 2004. PMID: 15623643
66 results