Hepatitis C virus (HCV) NS5A binds RNA-dependent RNA polymerase (RdRP) NS5B and modulates RNA-dependent RNA polymerase activity.
Shirota Y, Luo H, Qin W, Kaneko S, Yamashita T, Kobayashi K, Murakami S.
Shirota Y, et al.
J Biol Chem. 2002 Mar 29;277(13):11149-55. doi: 10.1074/jbc.M111392200. Epub 2002 Jan 18.
J Biol Chem. 2002.
PMID: 11801599
Free article.
Using terminally and internally truncated NS5A, two discontinuous regions of NS5A (amino acids 105-162 and 277-334) outside of the adaptive mutations were identified to be independently essential for the binding both in vivo and in vitro (Yamashita, T., Kaneko, S., Shirota …
Using terminally and internally truncated NS5A, two discontinuous regions of NS5A (amino acids 105-162 and 277-334) outside of the adaptive …