Ooms F - Search Results

1

(E)-8-(3-Chlorostyryl)-1,3,7-trimethylxanthine, a caffeine derivative acting both as antagonist of adenosine A2A receptors and as inhibitor of MAO-B.

Frédérick R, Ooms F, Castagnoli N Jr, Petzer JP, Feng JF, Schwarzschild MA, Van der Schyf CJ, Wouters J. Frédérick R, et al. Among authors: ooms f. Acta Crystallogr C. 2005 Sep;61(Pt 9):o531-2. doi: 10.1107/S0108270105023140. Epub 2005 Aug 10. Acta Crystallogr C. 2005. PMID: 16143772

2

Three 5H-indeno[1,2-c]pyridazin-5-one derivatives, potent type-B monoamine oxidase inhibitors.

Frédérick R, Norberg B, Durant F, Ooms F, Wouters J. Frédérick R, et al. Among authors: ooms f. Acta Crystallogr C. 2004 Sep;60(Pt 9):o623-6. doi: 10.1107/S0108270104014660. Epub 2004 Aug 11. Acta Crystallogr C. 2004. PMID: 15345837

3

Rational approaches towards reversible inhibition of type B monoamine oxidase. Design and evaluation of a novel 5H-Indeno[1,2-c]pyridazin-5-one derivative.

Ooms F, Frédérick R, Durant F, Petzer JP, Castagnoli N, Van der Schyf CJ, Wouters J. Ooms F, et al. Bioorg Med Chem Lett. 2003 Jan 6;13(1):69-73. doi: 10.1016/s0960-894x(02)00838-7. Bioorg Med Chem Lett. 2003. PMID: 12467619

4

Synthesis, structural reassignment, and biological activity of type B MAO inhibitors based on the 5H-indeno[1,2-c]pyridazin-5-one core.

Frédérick R, Dumont W, Ooms F, Aschenbach L, Van der Schyf CJ, Castagnoli N, Wouters J, Krief A. Frédérick R, et al. Among authors: ooms f. J Med Chem. 2006 Jun 15;49(12):3743-7. doi: 10.1021/jm051091j. J Med Chem. 2006. PMID: 16759116

5

Molecular interaction between reversible MAO-A inhibitors and the enzyme. Application to aryloxazolidinone, a prototype series.

Ooms F, Jegham S, George P, Durant F, Wouters J. Ooms F, et al. Neurobiology (Bp). 2000;8(1):81-98. Neurobiology (Bp). 2000. PMID: 11008880 Review.

6

Small molecule crystallography in drug design.

Wouters J, Ooms F. Wouters J, et al. Among authors: ooms f. Curr Pharm Des. 2001 May;7(7):529-45. doi: 10.2174/1381612013397889. Curr Pharm Des. 2001. PMID: 11375767 Review.

7

Molecular lipophilicity potential by CLIP, a reliable tool for the description of the 3D distribution of lipophilicity: application to 3-phenyloxazolidin-2-one, a prototype series of reversible MAOA inhibitors.

Ooms F, Wouters J, Collin S, Durant F, Jegham S, George P. Ooms F, et al. Bioorg Med Chem Lett. 1998 Jun 2;8(11):1425-30. doi: 10.1016/s0960-894x(98)00230-3. Bioorg Med Chem Lett. 1998. PMID: 9871778

8

Analysis of conserved active site residues in monoamine oxidase A and B and their three-dimensional molecular modeling.

Geha RM, Chen K, Wouters J, Ooms F, Shih JC. Geha RM, et al. Among authors: ooms f. J Biol Chem. 2002 May 10;277(19):17209-16. doi: 10.1074/jbc.M110920200. Epub 2002 Feb 22. J Biol Chem. 2002. PMID: 11861643 Free PMC article.

9

Exploration of the pharmacophore of 3-alkyl-5-arylimidazolidinediones as new CB(1) cannabinoid receptor ligands and potential antagonists: synthesis, lipophilicity, affinity, and molecular modeling.

Ooms F, Wouters J, Oscari O, Happaerts T, Bouchard G, Carrupt PA, Testa B, Lambert DM. Ooms F, et al. J Med Chem. 2002 Apr 25;45(9):1748-56. doi: 10.1021/jm010896y. J Med Chem. 2002. PMID: 11960486 Free article.

10

A simple model to predict blood-brain barrier permeation from 3D molecular fields.

Ooms F, Weber P, Carrupt PA, Testa B. Ooms F, et al. Biochim Biophys Acta. 2002 Jul 18;1587(2-3):118-25. doi: 10.1016/s0925-4439(02)00074-1. Biochim Biophys Acta. 2002. PMID: 12084453 Free article. Review.

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