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Are extensive T cell epitope polymorphisms in the Plasmodium falciparum circumsporozoite antigen, a leading sporozoite vaccine candidate, selected by immune pressure?
Kumkhaek C, Phra-Ek K, Rénia L, Singhasivanon P, Looareesuwan S, Hirunpetcharat C, White NJ, Brockman A, Grüner AC, Lebrun N, Alloueche A, Nosten F, Khusmith S, Snounou G. Kumkhaek C, et al. Among authors: snounou g. J Immunol. 2005 Sep 15;175(6):3935-9. doi: 10.4049/jimmunol.175.6.3935. J Immunol. 2005. PMID: 16148140
The Plasmodium falciparum knob-associated PfEMP3 antigen is also expressed at pre-erythrocytic stages and induces antibodies which inhibit sporozoite invasion.
Grüner AC, Brahimi K, Eling W, Konings R, Meis J, Aikawa M, Daubersies P, Guérin-Marchand C, Mellouk S, Snounou G, Druilhe P. Grüner AC, et al. Among authors: snounou g. Mol Biochem Parasitol. 2001 Feb;112(2):253-61. doi: 10.1016/s0166-6851(00)00373-x. Mol Biochem Parasitol. 2001. PMID: 11223132
206 results