Endothelin antagonist bosentan blocks neurogenic inflammation, but is not effective in aborting migraine attacks.
May A, Gijsman HJ, Wallnöfer A, Jones R, Diener HC, Ferrari MD.
May A, et al.
Pain. 1996 Oct;67(2-3):375-8. doi: 10.1016/0304-3959(96)03137-5.
Pain. 1996.
PMID: 8951932
Clinical Trial.
Bosentan, a specific mixed antagonist of endothelin receptors with no vasoconstrictor activity, inhibits neurogenic plasma extravasation (NPE) within rat dura mater. ...Thus, inhibition of NPE may not predict clinical efficacy of experimental antimigraine drugs. Vas …
Bosentan, a specific mixed antagonist of endothelin receptors with no vasoconstrictor activity, inhibits neurogenic plasma extravasat …