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Endothelin antagonist bosentan blocks neurogenic inflammation, but is not effective in aborting migraine attacks.
May A, Gijsman HJ, Wallnöfer A, Jones R, Diener HC, Ferrari MD. May A, et al. Pain. 1996 Oct;67(2-3):375-8. doi: 10.1016/0304-3959(96)03137-5. Pain. 1996. PMID: 8951932 Clinical Trial.
Bosentan, a specific mixed antagonist of endothelin receptors with no vasoconstrictor activity, inhibits neurogenic plasma extravasation (NPE) within rat dura mater. ...Thus, inhibition of NPE may not predict clinical efficacy of experimental antimigraine drugs. Vas …
Bosentan, a specific mixed antagonist of endothelin receptors with no vasoconstrictor activity, inhibits neurogenic plasma extravasat …
Substance P receptor antagonists in the therapy of migraine.
May A, Goadsby PJ. May A, et al. Expert Opin Investig Drugs. 2001 Apr;10(4):673-8. doi: 10.1517/13543784.10.4.673. Expert Opin Investig Drugs. 2001. PMID: 11281817 Review.
Modern antimigraine drugs, such as 5-HT(1B/D) agonists (triptans), block this dural neurogenic inflammation dose-dependently in an animal model but their vasoconstrictor effects have led to a search for non-vasoconstrictor approaches. One such approach has been substance P …
Modern antimigraine drugs, such as 5-HT(1B/D) agonists (triptans), block this dural neurogenic inflammation dose-dependently in an animal mo …
Autonomic activation in experimental trigeminal pain.
Frese A, Evers S, May A. Frese A, et al. Among authors: may a. Cephalalgia. 2003 Feb;23(1):67-8. doi: 10.1046/j.1468-2982.2003.00462.x. Cephalalgia. 2003. PMID: 12534584 No abstract available.
2,614 results