Pastan I - Search Results

1

Properties of chimeric toxins with two recognition domains: interleukin 6 and transforming growth factor alpha at different locations in Pseudomonas exotoxin.

Kreitman RJ, Siegall CB, Chaudhary VK, FitzGerald DJ, Pastan I. Kreitman RJ, et al. Among authors: pastan i. Bioconjug Chem. 1992 Jan-Feb;3(1):63-8. doi: 10.1021/bc00013a010. Bioconjug Chem. 1992. PMID: 1616951

2

Mik-beta 1(Fv)-PE40, a recombinant immunotoxin cytotoxic toward cells bearing the beta-chain of the IL-2 receptor.

Kreitman RJ, Schneider WP, Queen C, Tsudo M, Fitzgerald DJ, Waldmann TA, Pastan I. Kreitman RJ, et al. Among authors: pastan i. J Immunol. 1992 Oct 15;149(8):2810-5. J Immunol. 1992. PMID: 1401913

3

Recombinant toxins containing the variable domains of the anti-Tac monoclonal antibody to the interleukin-2 receptor kill malignant cells from patients with chronic lymphocytic leukemia.

Kreitman RJ, Chaudhary VK, Kozak RW, FitzGerald DJ, Waldman TA, Pastan I. Kreitman RJ, et al. Among authors: pastan i. Blood. 1992 Nov 1;80(9):2344-52. Blood. 1992. PMID: 1421405 Free article.

4

Alanine scanning mutagenesis identifies surface amino acids on domain II of Pseudomonas exotoxin required for cytotoxicity, proper folding, and secretion into periplasm.

Kasturi S, Kihara A, FitzGerald D, Pastan I. Kasturi S, et al. Among authors: pastan i. J Biol Chem. 1992 Nov 15;267(32):23427-33. J Biol Chem. 1992. PMID: 1429683 Free article.

5

Cell-mediated cleavage of Pseudomonas exotoxin between Arg279 and Gly280 generates the enzymatically active fragment which translocates to the cytosol.

Ogata M, Fryling CM, Pastan I, FitzGerald DJ. Ogata M, et al. Among authors: pastan i. J Biol Chem. 1992 Dec 15;267(35):25396-401. J Biol Chem. 1992. PMID: 1460035 Free article.

Pseudomonas exotoxin (PE) is a three-domain toxin which is cleaved by a cellular protease within cells and then reduced to generate two prominent fragments (Ogata, M., Chaudhary, V. K., Pastan, I., and FitzGerald, D. J. (1990) J. Biol. Chem. 265, 20678-20685). The N …

Pseudomonas exotoxin (PE) is a three-domain toxin which is cleaved by a cellular protease within cells and then reduced to generate two prom …

6

Pseudomonas exotoxin: recombinant conjugates as therapeutic agents.

FitzGerald DJ, Pastan I. FitzGerald DJ, et al. Among authors: pastan i. Biochem Soc Trans. 1992 Nov;20(4):731-4. doi: 10.1042/bst0200731. Biochem Soc Trans. 1992. PMID: 1487051 Review. No abstract available.

7

In vitro and in vivo suppression of interleukin-2-activated killer cell activity by chimeric proteins between interleukin-2 and Pseudomonas exotoxin.

Puri RK, FitzGerald D, Leland P, Kozak RW, Pastan I. Puri RK, et al. Among authors: pastan i. Cell Immunol. 1992 Sep;143(2):324-34. doi: 10.1016/0008-8749(92)90029-o. Cell Immunol. 1992. PMID: 1511480

8

A recombinant form of Pseudomonas exotoxin directed at the epidermal growth factor receptor that is cytotoxic without requiring proteolytic processing.

Theuer CP, FitzGerald D, Pastan I. Theuer CP, et al. Among authors: pastan i. J Biol Chem. 1992 Aug 25;267(24):16872-7. J Biol Chem. 1992. PMID: 1512230 Free article.

9

Alteration of a protease-sensitive region of Pseudomonas exotoxin prolongs its survival in the circulation of mice.

Brinkmann U, Pai LH, FitzGerald DJ, Pastan I. Brinkmann U, et al. Among authors: pastan i. Proc Natl Acad Sci U S A. 1992 Apr 1;89(7):3065-9. doi: 10.1073/pnas.89.7.3065. Proc Natl Acad Sci U S A. 1992. PMID: 1557414 Free PMC article.

10

Interleukin-6 fused to a mutant form of Pseudomonas exotoxin kills malignant cells from patients with multiple myeloma.

Kreitman RJ, Siegall CB, FitzGerald DJ, Epstein J, Barlogie B, Pastan I. Kreitman RJ, et al. Among authors: pastan i. Blood. 1992 Apr 1;79(7):1775-80. Blood. 1992. PMID: 1558971 Free article.

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