Mucke L - Search Results

1

SIRT1 protects against microglia-dependent amyloid-beta toxicity through inhibiting NF-kappaB signaling.

Chen J, Zhou Y, Mueller-Steiner S, Chen LF, Kwon H, Yi S, Mucke L, Gan L. Chen J, et al. Among authors: mucke l. J Biol Chem. 2005 Dec 2;280(48):40364-74. doi: 10.1074/jbc.M509329200. Epub 2005 Sep 23. J Biol Chem. 2005. PMID: 16183991 Free article.

2

Levels and alternative splicing of amyloid beta protein precursor (APP) transcripts in brains of APP transgenic mice and humans with Alzheimer's disease.

Rockenstein EM, McConlogue L, Tan H, Power M, Masliah E, Mucke L. Rockenstein EM, et al. Among authors: mucke l. J Biol Chem. 1995 Nov 24;270(47):28257-67. doi: 10.1074/jbc.270.47.28257. J Biol Chem. 1995. PMID: 7499323 Free article.

Recently, a transgenic model was established in which platelet-derived growth factor (PDGF) promoter-driven neuronal expression of an alternatively spliced hAPP minigene resulted in prominent AD-type neuropathology (Games, D., Adams, D., Alessandrini, R., Barbour, R., Berthelette …

Recently, a transgenic model was established in which platelet-derived growth factor (PDGF) promoter-driven neuronal expression of an altern …

3

Beta-secretase processing of the beta-amyloid precursor protein in transgenic mice is efficient in neurons but inefficient in astrocytes.

Zhao J, Paganini L, Mucke L, Gordon M, Refolo L, Carman M, Sinha S, Oltersdorf T, Lieberburg I, McConlogue L. Zhao J, et al. Among authors: mucke l. J Biol Chem. 1996 Dec 6;271(49):31407-11. doi: 10.1074/jbc.271.49.31407. J Biol Chem. 1996. PMID: 8940150 Free article.

4

Amyloid protein precursor stimulates excitatory amino acid transport. Implications for roles in neuroprotection and pathogenesis.

Masliah E, Raber J, Alford M, Mallory M, Mattson MP, Yang D, Wong D, Mucke L. Masliah E, et al. Among authors: mucke l. J Biol Chem. 1998 May 15;273(20):12548-54. doi: 10.1074/jbc.273.20.12548. J Biol Chem. 1998. PMID: 9575214 Free article.

5

Wild-type but not Alzheimer-mutant amyloid precursor protein confers resistance against p53-mediated apoptosis.

Xu X, Yang D, Wyss-Coray T, Yan J, Gan L, Sun Y, Mucke L. Xu X, et al. Among authors: mucke l. Proc Natl Acad Sci U S A. 1999 Jun 22;96(13):7547-52. doi: 10.1073/pnas.96.13.7547. Proc Natl Acad Sci U S A. 1999. PMID: 10377452 Free PMC article.

6

TGF-beta1 promotes microglial amyloid-beta clearance and reduces plaque burden in transgenic mice.

Wyss-Coray T, Lin C, Yan F, Yu GQ, Rohde M, McConlogue L, Masliah E, Mucke L. Wyss-Coray T, et al. Among authors: mucke l. Nat Med. 2001 May;7(5):612-8. doi: 10.1038/87945. Nat Med. 2001. PMID: 11329064

7

Neuronal depletion of calcium-dependent proteins in the dentate gyrus is tightly linked to Alzheimer's disease-related cognitive deficits.

Palop JJ, Jones B, Kekonius L, Chin J, Yu GQ, Raber J, Masliah E, Mucke L. Palop JJ, et al. Among authors: mucke l. Proc Natl Acad Sci U S A. 2003 Aug 5;100(16):9572-7. doi: 10.1073/pnas.1133381100. Epub 2003 Jul 24. Proc Natl Acad Sci U S A. 2003. PMID: 12881482 Free PMC article.

8

Intracellularly generated amyloid-beta peptide counteracts the antiapoptotic function of its precursor protein and primes proapoptotic pathways for activation by other insults in neuroblastoma cells.

Esposito L, Gan L, Yu GQ, Essrich C, Mucke L. Esposito L, et al. Among authors: mucke l. J Neurochem. 2004 Dec;91(6):1260-74. doi: 10.1111/j.1471-4159.2004.02816.x. J Neurochem. 2004. PMID: 15584903 Free article.

9

High beta-secretase activity elicits neurodegeneration in transgenic mice despite reductions in amyloid-beta levels: implications for the treatment of Alzheimer disease.

Rockenstein E, Mante M, Alford M, Adame A, Crews L, Hashimoto M, Esposito L, Mucke L, Masliah E. Rockenstein E, et al. Among authors: mucke l. J Biol Chem. 2005 Sep 23;280(38):32957-67. doi: 10.1074/jbc.M507016200. Epub 2005 Jul 15. J Biol Chem. 2005. PMID: 16027115 Free article.

10

Antiamyloidogenic and neuroprotective functions of cathepsin B: implications for Alzheimer's disease.

Mueller-Steiner S, Zhou Y, Arai H, Roberson ED, Sun B, Chen J, Wang X, Yu G, Esposito L, Mucke L, Gan L. Mueller-Steiner S, et al. Among authors: mucke l. Neuron. 2006 Sep 21;51(6):703-14. doi: 10.1016/j.neuron.2006.07.027. Neuron. 2006. PMID: 16982417 Free article.

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