McCague R - Search Results

1

On-line continuous-flow dialysis thermospray tandem mass spectrometry for quantitative screening of drugs in plasma: rogletimide.

van Bakergem E, van der Hoeven RA, Niessen WM, Tjaden UR, van der Greef J, Poon GK, McCague R. van Bakergem E, et al. Among authors: mccague r. J Chromatogr. 1992 May 15;598(2):189-94. doi: 10.1016/0021-9673(92)85047-w. J Chromatogr. 1992. PMID: 1618979

2

Identification of 4-hydroxyandrost-4-ene-3,17-dione metabolites in prostatic cancer patients by liquid chromatography-mass spectrometry.

Poon GK, Jarman M, McCague R, Davies JH, Heeremans CE, van der Hoeven RA, Niessen WM, van der Greef J. Poon GK, et al. Among authors: mccague r. J Chromatogr. 1992 May 8;576(2):235-44. doi: 10.1016/0378-4347(92)80197-x. J Chromatogr. 1992. PMID: 1400711

3

Characterisation of metabolites of 3-ethyl-3-(4-pyridyl)-piperidine-2,6-dione, a potential breast cancer drug.

Poon GK, McCague R, Griggs LJ, Jarman M, Lewis IA. Poon GK, et al. Among authors: mccague r. J Chromatogr. 1991 Dec 6;572(1-2):143-57. doi: 10.1016/0378-4347(91)80479-v. J Chromatogr. 1991. PMID: 1818050

4

Analysis of phase I and phase II metabolites of tamoxifen in breast cancer patients.

Poon GK, Chui YC, McCague R, Lłnning PE, Feng R, Rowlands MG, Jarman M. Poon GK, et al. Among authors: mccague r. Drug Metab Dispos. 1993 Nov-Dec;21(6):1119-24. Drug Metab Dispos. 1993. PMID: 7905393

5

The deuterium isotope effect for the alpha-hydroxylation of tamoxifen by rat liver microsomes accounts for the reduced genotoxicity of [D5-ethyl]tamoxifen.

Jarman M, Poon GK, Rowlands MG, Grimshaw RM, Horton MN, Potter GA, McCague R. Jarman M, et al. Among authors: mccague r. Carcinogenesis. 1995 Apr;16(4):683-8. doi: 10.1093/carcin/16.4.683. Carcinogenesis. 1995. PMID: 7728943

6

Identification of tamoxifen metabolites in human Hep G2 cell line, human liver homogenate, and patients on long-term therapy for breast cancer.

Poon GK, Walter B, Lønning PE, Horton MN, McCague R. Poon GK, et al. Among authors: mccague r. Drug Metab Dispos. 1995 Mar;23(3):377-82. Drug Metab Dispos. 1995. PMID: 7628304

7

Conformational analysis of the aromatase inhibitor 3-ethyl-3-(4-pyridyl)piperidine-2,6-dione (rogletimide) and discovery of potent 5-alkyl derivatives.

McCague R, Rowlands MG. McCague R, et al. J Med Chem. 1992 Oct 2;35(20):3699-704. doi: 10.1021/jm00098a016. J Med Chem. 1992. PMID: 1433182

8

Crystallographic and molecular modeling studies on 3-ethyl-3-(4-pyridyl)piperidine-2,6-dione and its butyl analogue, inhibitors of mammalian aromatase. Comparison with natural substrates: prediction of enantioselectivity for N-alkyl derivatives.

Laughton CA, McKenna R, Neidle S, Jarman M, McCague R, Rowlands MG. Laughton CA, et al. Among authors: mccague r. J Med Chem. 1990 Sep;33(9):2673-9. doi: 10.1021/jm00171a052. J Med Chem. 1990. PMID: 2391706

9

Octafluorotoluene as a derivatizing agent for steroids in human plasma.

Baker MH, Howe I, Jarman M, McCague R. Baker MH, et al. Among authors: mccague r. Biomed Environ Mass Spectrom. 1988 Oct;16(1-12):211-3. doi: 10.1002/bms.1200160138. Biomed Environ Mass Spectrom. 1988. PMID: 3242672

10

A mechanistic hypothesis for DNA adduct formation by tamoxifen following hepatic oxidative metabolism.

Potter GA, McCague R, Jarman M. Potter GA, et al. Among authors: mccague r. Carcinogenesis. 1994 Mar;15(3):439-42. doi: 10.1093/carcin/15.3.439. Carcinogenesis. 1994. PMID: 8118925

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