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Inhibition of acetylcholinesterase by the anticancer prodrug CPT-11.
Hyatt JL, Tsurkan L, Morton CL, Yoon KJ, Harel M, Brumshtein B, Silman I, Sussman JL, Wadkins RM, Potter PM. Hyatt JL, et al. Chem Biol Interact. 2005 Dec 15;157-158:247-52. doi: 10.1016/j.cbi.2005.10.033. Epub 2005 Oct 28. Chem Biol Interact. 2005. PMID: 16257398
An improved human carboxylesterase for enzyme/prodrug therapy with CPT-11.
Wierdl M, Tsurkan L, Hyatt JL, Edwards CC, Hatfield MJ, Morton CL, Houghton PJ, Danks MK, Redinbo MR, Potter PM. Wierdl M, et al. Among authors: hyatt jl. Cancer Gene Ther. 2008 Mar;15(3):183-92. doi: 10.1038/sj.cgt.7701112. Epub 2008 Jan 11. Cancer Gene Ther. 2008. PMID: 18188187
The crystal structure of the complex of the anticancer prodrug 7-ethyl-10-[4-(1-piperidino)-1-piperidino]-carbonyloxycamptothecin (CPT-11) with Torpedo californica acetylcholinesterase provides a molecular explanation for its cholinergic action.
Harel M, Hyatt JL, Brumshtein B, Morton CL, Yoon KJ, Wadkins RM, Silman I, Sussman JL, Potter PM. Harel M, et al. Among authors: hyatt jl. Mol Pharmacol. 2005 Jun;67(6):1874-81. doi: 10.1124/mol.104.009944. Epub 2005 Mar 16. Mol Pharmacol. 2005. PMID: 15772291
Activation and antitumor activity of CPT-11 in plasma esterase-deficient mice.
Morton CL, Iacono L, Hyatt JL, Taylor KR, Cheshire PJ, Houghton PJ, Danks MK, Stewart CF, Potter PM. Morton CL, et al. Among authors: hyatt jl. Cancer Chemother Pharmacol. 2005 Dec;56(6):629-36. doi: 10.1007/s00280-005-1027-y. Epub 2005 May 26. Cancer Chemother Pharmacol. 2005. PMID: 15918039
The 3D structure of the anticancer prodrug CPT-11 with Torpedo californica acetylcholinesterase rationalizes its inhibitory action on AChE and its hydrolysis by butyrylcholinesterase and carboxylesterase.
Harel M, Hyatt JL, Brumshtein B, Morton CL, Wadkins RM, Silman I, Sussman JL, Potter PM. Harel M, et al. Among authors: hyatt jl. Chem Biol Interact. 2005 Dec 15;157-158:153-7. doi: 10.1016/j.cbi.2005.10.016. Epub 2005 Nov 14. Chem Biol Interact. 2005. PMID: 16289500
44 results