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The 3D structure of the anticancer prodrug CPT-11 with Torpedo californica acetylcholinesterase rationalizes its inhibitory action on AChE and its hydrolysis by butyrylcholinesterase and carboxylesterase.
Harel M, Hyatt JL, Brumshtein B, Morton CL, Wadkins RM, Silman I, Sussman JL, Potter PM. Harel M, et al. Among authors: wadkins rm. Chem Biol Interact. 2005 Dec 15;157-158:153-7. doi: 10.1016/j.cbi.2005.10.016. Epub 2005 Nov 14. Chem Biol Interact. 2005. PMID: 16289500
The crystal structure of the complex of the anticancer prodrug 7-ethyl-10-[4-(1-piperidino)-1-piperidino]-carbonyloxycamptothecin (CPT-11) with Torpedo californica acetylcholinesterase provides a molecular explanation for its cholinergic action.
Harel M, Hyatt JL, Brumshtein B, Morton CL, Yoon KJ, Wadkins RM, Silman I, Sussman JL, Potter PM. Harel M, et al. Among authors: wadkins rm. Mol Pharmacol. 2005 Jun;67(6):1874-81. doi: 10.1124/mol.104.009944. Epub 2005 Mar 16. Mol Pharmacol. 2005. PMID: 15772291
Inhibition of acetylcholinesterase by the anticancer prodrug CPT-11.
Hyatt JL, Tsurkan L, Morton CL, Yoon KJ, Harel M, Brumshtein B, Silman I, Sussman JL, Wadkins RM, Potter PM. Hyatt JL, et al. Among authors: wadkins rm. Chem Biol Interact. 2005 Dec 15;157-158:247-52. doi: 10.1016/j.cbi.2005.10.033. Epub 2005 Oct 28. Chem Biol Interact. 2005. PMID: 16257398
Modifications of human carboxylesterase for improved prodrug activation.
Hatfield JM, Wierdl M, Wadkins RM, Potter PM. Hatfield JM, et al. Among authors: wadkins rm. Expert Opin Drug Metab Toxicol. 2008 Sep;4(9):1153-65. doi: 10.1517/17425255.4.9.1153. Expert Opin Drug Metab Toxicol. 2008. PMID: 18721110 Free PMC article. Review.
53 results